50693-82-8Relevant academic research and scientific papers
In Vitro and in Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas
Ottavi, Samantha,Scarry, Sarah M.,Mosior, John,Ling, Yan,Roberts, Julia,Singh, Amrita,Zhang, David,Goullieux, Laurent,Roubert, Christine,Bacqué, Eric,Lagiakos, H. Rachel,Vendome, Jeremie,Moraca, Francesca,Li, Kelin,Perkowski, Andrew J.,Ramesh, Remya,Bowler, Matthew M.,Tracy, William,Feher, Victoria A.,Sacchettini, James C.,Gold, Ben S.,Nathan, Carl F.,Aubé, Jeffrey
, p. 1996 - 2022 (2022/01/31)
A newly validated target for tuberculosis treatment is phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. The structure-activity relat
Preparation method of 5-n-butyl-2-ethylamino-4-hydroxy-6-methylpyrimidine
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Paragraph 0032-0033; 0035-0036; 0038-0039; 0041-0042; 0044, (2021/04/21)
The invention discloses a preparation method of 5-n-butyl-2-ethylamino-4-hydroxy-6-methylpyrimidine, which comprises the following steps: by using ethylamine and cyanamide as initial raw materials, generating N-ethylguanidine sulfate under the action of concentrated sulfuric acid, reacting with 2-n-butyl ethyl acetoacetate under the action of sodium hydroxide for 1-4 hours, and carrying out after-treatment to obtain 5-n-butyl-2-ethylamino-4-hydroxy-6-methylpyrimidine. According to the method, cheap and easily available ethylamine and cyanamide are used as initial raw materials, the method is green and environment-friendly, isomers are separated by using a preparative chromatography technology, the yield and purity of the product are relatively high, and the method has a wide industrial application prospect.
