65009-19-0Relevant academic research and scientific papers
In Vitro and in Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas
Bowler, Matthew M.,Feher, Victoria A.,Gold, Ben S.,Goullieux, Laurent,Lagiakos, H. Rachel,Li, Kelin,Ling, Yan,Moraca, Francesca,Mosior, John,Nathan, Carl F.,Ottavi, Samantha,Perkowski, Andrew J.,Ramesh, Remya,Roberts, Julia,Roubert, Christine,Sacchettini, James C.,Scarry, Sarah M.,Singh, Amrita,Tracy, William,Vendome, Jeremie,Zhang, David,Aubé, Jeffrey,Bacqué, Eric
, (2022/01/31)
A newly validated target for tuberculosis treatment is phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. The structure-activity relat
