50702-51-7

Usage

Uses

Used in Pharmaceutical Synthesis:
(3-Fluorophenyl)hydrazine hydrochloride is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, making it a valuable component in medicinal chemistry.
Used in Agrochemical Development:
In the agrochemical industry, (3-Fluorophenyl)hydrazine hydrochloride serves as an essential building block for the creation of new pesticides and other agricultural chemicals. Its incorporation can lead to the development of more effective and targeted products for crop protection and management.
Used in Dye Manufacturing:
(3-Fluorophenyl)hydrazine hydrochloride is utilized in the production of dyes due to its ability to impart color and stability to these compounds. Its presence in dye formulations can enhance their performance and applicability in various industries, such as textiles and printing.
Used as an Intermediate in Organic Chemical Reactions:
Beyond its direct applications, (3-Fluorophenyl)hydrazine hydrochloride also functions as an intermediate in a variety of organic chemical reactions. Its reactivity and structural features make it a useful component in the synthesis of other complex organic compounds for research and industrial purposes.
It is crucial to handle (3-Fluorophenyl)hydrazine hydrochloride with care, as it can pose hazards if not properly managed. Its versatility and applications across multiple industries underscore the importance of safe and responsible use.

Upstream product

• 372-19-0 meta-fluoroaniline 
• 1121-86-4 1-Fluoro-3-iodobenzene 
• 658-27-5 m-fluorophenylhydrazine 

Downstream Products

• 94568-97-5 3-(3-Fluoro-phenyl)-5,7-dimethyl-4-oxo-3,4-dihydro-phthalazine-1,6-dicarboxylic acid diethyl ester 
• 1257412-01-3 C₁₀H₆F₄N₂O 
• 58861-54-4 2-(3-fluorophenyl)pyridine 
• 79412-32-1 3-(m-fluorophenyl)pyridine 
• 69099-29-2 1-(3-fluoro-phenyl)-1,4-dihydro-thiochromeno[4,3-c]pyrazole-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Design, Synthesis, and Antifungal Activity of 2,6-Dimethyl-4-aminopyrimidine Hydrazones as PDHc-E1 Inhibitors with a Novel Binding Mode

A series of novel 2,6-dimethyl-4-aminopyrimidine hydrazones 5 were rationally designed and synthesized as pyruvate dehydrogenase complex E1 (PDHc-E1) inhibitors. Compounds 5 strongly inhibited Escherichia coli (E. coli) PDHc-E1 (IC50 values 0.94-15.80 μM). As revealed by molecular docking, site-directed mutagenesis, enzymatic, and inhibition kinetic analyses, compounds 5 competitively inhibited PDHc-E1 and bound in a "straight"pattern at the E. coli PDHc-E1 active site, which is a new binding mode. In in vitro antifungal assays, most compounds 5 at 50 μg/mL showed more than 80% inhibition against the mycelial growth of six tested phytopathogenic fungi, including Botrytis cinerea, Monilia fructigena, Colletotrichum gloeosporioides, andBotryosphaeria dothidea. Notably, 5f and 5i were 1.8-380 fold more potent against M. fructigena than the commercial fungicides captan and chlorothalonil. In vivo, 5f and 5i controlled the growth of M. fructigena comparably to the commercial fungicide tebuconazole. Thus, 5f and 5i have potential commercial value for the control of peach brown rot caused by M. fructigena.

Substituted indole urea derivative, synthetic method and application thereof

The invention discloses a substituted indole urea derivative, a synthesis method and application thereof. The structure is shown as a formula I. In the formula, the definition of each substituent group is described in the specification and claims. The compound disclosed by the invention can be used as a cGAS-STING pathway targeting inhibitor and is used for treating inflammatory diseases and autoimmune diseases.

Synthesis of Aryl Hydrazines via CuI/BMPO Catalyzed Cross-Coupling of Aryl Halides with Hydrazine Hydrate in Water

The N,N’-bis(2,6-dimethylphenyl)oxalamide was discovered as a powerful ligand for Cu-catalyzed cross-coupling of aryl halides with hydrazine hydrate, leading to the formation of a variety of aryl hydrazines at 80 oC in water under the assistance of K3PO4 and 4 mol% cetyltrimethylammonium bromide from aryl bromides and aryl iodides. Good to excellent yields were observed in most cases.

Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents

A series of glutamic acid derivatives was synthesized and evaluated for their antioxidant activity and stability. We found several potent and stable glutamic acid derivatives. Among them, compound 12b exhibited good in vitro activity, chemical stability and cytotoxicity. A prototype compound 12b showed an anti-inflammatory effect in LPS-stimulated RAW 264.7 cell lines and in a zebrafish model.

Preparation method for 3-fluorophenylhydrazine hydrochloride

The invention relates to a preparation method for 3-fluorophenylhydrazine hydrochloride. The preparation method comprises the following steps: diazotization, reduction, purification and salt formation. During diazotization and reduction, concentrated hydrochloric acid enables a reaction solution to maintain highly acidic, so smooth and complete reaction is guaranteed. In the step of reduction, zinc dust-concentrated hydrochloric acid is used as a reducing agent to replace sodium hyposulfite, sodium bisulfate, stannous chloride-hydrochloric acid, etc., and the zinc dust-concentrated hydrochloric acid is good in reducing property and high in yield, shortens reaction time, enables impurities like zinc hydroxide produced after the reaction to be easy to remove and allows produced 3-fluorophenylhydrazine hydrochloride to be low in impurity content and high in purity. In the step of salt formation, acetone is used for leaching, so product purity is improved and product appearance is guaranteed. The preparation method is stable and reliable in process and easy to operate; and produced 3-fluorophenylhydrazine hydrochloride is high in purity (no less than 99% according to the results of content measurement via high performance liquid chromatography), has a yield of no less than 39% and completely meets market demands for 3-fluorophenylhydrazine hydrochloride.

Synthesis, crystal structure and fungicidal activities of new type oxazolidinone-based strobilurin analogues

A series of oxazolidinone-based strobilurin analogues were efficiently synthesized by the reaction of 3-(2-bromomethylphenyl) oxazolidin-2-one with 1-substituted phenyl-2H-pyrazolin-3-one. Their structures were confirmed and characterized by 1H-NMR, 13C-NMR, elemental analysis, and mass spectroscopy. In addition, the crystal structure of the target compound 3-(2-((1-phenyl-2H-pyrazol-3-yloxy)methyl)phenyl) oxazolidin-2-one was determined by single crystal X-ray diffraction. The bioassay results of these compounds indicated that some of the oxazolidin-2-one derivatives containing N-substituted phenyl 2H-pyrazol ring exhibited potential in vivo fungicidal activities against M. grisea at the dosage of 1 g L-1.

New Heterocyclic compounds for therapeutic use

A class of compounds particularly diaryl pyrazole of general formulas 1 and 2 where R and R′ represents alkyl, hydrogen, halogens, haloalkyl, cyano, nitro, formyl, carboxyl, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, hydroxyalkyl, alkylthio, alkylsulfinyl, alkylsulphonyl, N- alkylsulfamyl, N-arylsulfamyl, cyanoamido, amino, amidino, N-monoalkylamido, N-monoarylamido, N,N-dialkylamido, N-alkyl-N-arylamido, N, N-dialkylsulfamyl with the alkyl, or alkyl part of each such group containing 1-3 carbon atoms or mixtures thereof optionally their salts when they exist, and preparation thereof. The compounds of the present invention are antiinflammatory, antipyretic, antirheumatic, antiosteoarthritic agents with antibacterial activity. The particular class of compounds is given below (Formula 1 and Formula 2).

Lipoxygenase Inhibitors, III: Synthesis of Tetrahydrobenzazepinone Phenylhydrazones

Tetrahydro-2H-benzazepin-2-ones as starting substances are synthesized by Beckmann rearrangement or Schmidt reaction.The tetrahydrobenzazepinones are transformed into the thiones, thiolactim ethers and phenylhydrazones.The compounds are tested as inhibitors of soja lipoxygenase.