914654-71-0Relevant academic research and scientific papers
Palladium-catalyzed monoarylation of arylhydrazines with aryl tosylates
Huang, Yange,Choy, Pui Ying,Wang, Junya,Tse, Man-Kin,Raymond Wai-Yin Sun,Albert Sun-Chi Chan,Kwong, Fuk Yee
, p. 14664 - 14673 (2020/12/29)
A palladium-catalyzed C-N bond coupling reaction between arylhydrazines and aryl tosylates for facile synthesis of unsymmetrical N,N-diarylhydrazines has been developed. Employing the catalyst system of Pd(TFA)2 associated with newly developed phosphine ligand L1, the monoarylation of arylhydrazine proceeds smoothly to afford desired products in good-to-excellent yields (up to 95%) with good functional group compatibility. This method provides an alternative synthetic pathway for accessing structurally diversified N,N-diarylhydrazines from simple and easily accessible coupling components.
Photoinduced cleavage of N-N bonds of aromatic hydrazines and hydrazides by visible light
Zhu, Mingzhao,Zheng, Nan
, p. 2223 - 2236 (2011/09/15)
A photocatalytic system involving [Ru(bpyrz)(PFH, visible light, and air has been developed for cleavage of the N-N bonds of hydrazines and hydrazides. This catalytic system is generally effective for N,N-disubstituted hydrazine and hydrazide derivatives, including arylhydrazides, N-alkyl-N-arylhydrazines, and N,N-diarylhydrazines. The utility of this cleavage reaction has been demonstrated by synthesizing a variety of secondary aromatic amines. Georg Thieme Verlag Stuttgart ? New York.
Quinoline derivatives as neurokinin receptor antagonists
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Page/Page column 34, (2009/04/24)
The present invention relates to substituted quinoline hydrazides of Formula (I): wherein R1, R2, R3, R4, R5, X, Y and Z are defined herein, pharmaceutical compositions comprising them and their use in treating diseases mediated by neurokinin-2 and/or neurokinin-3 (NK-3) receptors. These compounds can thus be used in methods of treatment to suppress and treat such disorders.
