50706-19-9Relevant academic research and scientific papers
Synthesis of L-β-hydroxyaminoacids using serine hydroxymethyltransferase
Saeed, Ashraf,Young, Douglas W.
, p. 2507 - 2514 (2007/10/02)
The enzyme serine hydroxymethyltransferase (EC 2.1.2.1) has been used in the synthetic direction with a variety of aldehyde substrates to form carbon---carbon bonds with the creation of two chiral centres. A variety of β-hydroxyaminoacids has been prepared in reasonable yields but, although L-stereo specificity is observed at the α-centre, stereospecificity is not high at the β-centre when the reaction is conducted on the preparative scale.
Iodocyclization of the (Tolylsulfonyl)- and (Trichloroacetyl)carbamates of Secondary α-Allenic Alcohols. Highly Diastereoselective Synthesis of syn-1,2-Amino Alcohols and trans-5-Alkyl-1-oxo-2-oxazolidine-4-carboxylic Acids
Friesen, Richard W.,Kolaczewska, Aleksandra E.
, p. 4888 - 4895 (2007/10/02)
The iodocyclization of tosyl- and (trichloroacetyl)carbamates 9 and 10, respectively, of secondary α-allenic alcohols is described.The cyclofunctionalization reactions are highly diastereoselective, providing trans-5-alkyl-4-(1-iodoethylene)-2-oxazolidino
RAPID SYNTHESIS OF β-HYDROXY-α-AMINO ACIDS, SUCH AS L-THREONINE, β-HYDROXYPHENYLALANINE, AND β-HYDROXYLEUCINE, VIA AN APPLICATION OF THE SHARPLESS ASYMMETRIC EPOXIDATION
Jung, Michael E.,Jung, Young H.
, p. 6637 - 6640 (2007/10/02)
The optically active epoxy alcohols 6abc, prepared by a Sharpless kinetic resolution-epoxidation process, were converted to the optically pure β-hydroxy-α-amino acids 1abc in four steps and high overall yield.
