50709-88-1

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-CHLOROPHENYL)-2-(PHENYLSULFONYL)ACRYLONITRILE is used as an intermediate in the synthesis of various pharmaceuticals for its role in creating complex organic compounds that can exhibit therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical industry, 3-(4-CHLOROPHENYL)-2-(PHENYLSULFONYL)ACRYLONITRILE serves as an intermediate, contributing to the development of compounds that can be used in crop protection and other agricultural applications.
Used in Dye and Pigment Production:
3-(4-CHLOROPHENYL)-2-(PHENYLSULFONYL)ACRYLONITRILE is utilized in the production of dyes and pigments, capitalizing on its chemical properties to create a range of colorants for various industries.
Used in Material Science:
As a building block in material science, 3-(4-CHLOROPHENYL)-2-(PHENYLSULFONYL)ACRYLONITRILE is used for the development of new materials and organic compounds, potentially leading to advancements in numerous fields.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 3-(4-CHLOROPHENYL)-2-(PHENYLSULFONYL)ACRYLONITRILE is studied for its potential anticancer and anti-inflammatory properties, with ongoing research aimed at understanding and harnessing these effects for therapeutic applications.

InChI:InChI=1/C15H10ClNO2S/c16-13-8-6-12(7-9-13)10-15(11-17)20(18,19)14-4-2-1-3-5-14/h1-10H/b15-10+

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 7605-28-9 2-(phenylsulfonyl)acetonitrile 
• 873-55-2 sodium benzenesulfonate 
• 107-14-2 chloroacetonitrile 

Downstream Products

• 28446-72-2 (2E)-3-(4-chlorophenyl)acrylonitrile 
• 32327-71-2 3-(4-chlorophenyl)propanenitrile 
• 507265-90-9 2-(4-chloro-phenyl)-4-imino-9,10-dimethoxy-6,7-dihydro-4H-pyrido[2,1-a]isoquinoline-1-carbonitrile 
• 1426536-99-3 (+)-ethyl 2-(2R-cyano-4S-nitro-3R-(4-chlorophenyl)-2R-(phenylsulfonyl)-1S-cyclohexyl)acetate 
• 1426537-09-8 ethyl 2-(2R-cyano-4S-nitro-3R-(4-chlorophenyl)-2R-(phenylsulfonyl)-1R-cyclohexyl)acetate 
• 1563174-85-5 4-(4-chlorophenyl)-3-tosyl-1H-pyrazole-5-carbonitrile 

Relevant academic research and scientific papers

Organocatalytic Cascade Knoevenagel–Michael Addition Reactions: Direct Synthesis of Polysubstituted 2-Amino-4H-Chromene Derivatives

Abstract: In this report, we documented novel strategy for the synthesis of bioactive polysubstituted 2-amino-4H-chromine derivatives under a heterogeneous Al-MCM-41-LDH@APTES (ALAM) catalysis. A synthetic procedure is developed to prepare Al-MCM-41-LDH@APTES (ALAM) heterogeneous basic catalysts. Mesoporous Al-MCM-41 is functionalized by known grafting chemistry via layered double hydroxide (LDH) nanosheets and (3-aminopropyl)triethoxysilane (APTES) moiety as a basic organocatalyst. The resulting catalysts contain amino group functionality on the external surface as well as inside the layers and the basicity can be tuned by the loading of APTES. The samples were fully characterized by 29Si and 13C CP/MAS NMR, infrared absorption spectroscopy, TEM, XPS, EDX, TGA, XRD, CO2-TPD, N2 adsorption isotherms measurements, and they were successfully examined for the cascade type Knoevenagel–Michael addition reactions. The product yields associated with these substrates were optimized, and key reaction parameters affecting the yields were identified. The present catalytic method is simple and robust for diversity oriented synthesis which proceeds good to excellent yields without generating any hazards waste. The broad substrate scope, excellent functional group compatibility makes this protocol highly useful towards synthesis of polysubstituted α-cyanoacrylates, α-cyanoacrylonitriles and 2-amino-4H-chromenes with an electron-donating or electron-withdrawing group. We have also successfully established a flow reaction system, gram-scale synthesis as well as catalyst recyclability up to six catalytic cycles without appreciable loss of its activity. Graphic Abstract: [Figure not available: see fulltext.].

Green approach to synthesis of new series of 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives

One-pot, three-component condensation reaction between (phenylsulfonyl)acetonitrile, aromatic aldehydes, and 6-aminouracil for preparation of 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives has been reported. The method involves domino Knoevenagel condens

Green approach to synthesis of novel and broad-range diversity of 4-(aryl)-3-(phenylsulfonyl)-4H-benzo[h]chromen-2-amine derivatives

Abstract: One-pot, three-component condensation reaction between (phenylsulfonyl)acetonitrile, aromatic aldehydes, and α-naphthol for preparation of 4-(aryl)-3-(phenylsulfonyl)-4H-benzo[h]chromen-2-amine derivatives has been reported. The method involves

Organocatalytic domino reaction of cyanosulfones: Access to complex cyclohexane systems with quaternary carbon centers

When ε-nitro-α,β-unsaturated esters are added to conjugated cyanosulfones in the presence of a bifunctional thiourea catalyst, a highly stereoselective domino reaction occurs to generate complex cyclohexanes with up to four stereogenic centers, one of whi

One-step synthesis of α,β-unsaturated arylsulfones by a novel multicomponent reaction of aromatic aldehydes, chloroacetonitrile, benzenesulfinic acid sodium salt

A new and green method for the synthesis of α,β-unsaturated arylsulfones had been achieved through the condensation of aromatic aldehydes, chloroacetonitrile, benzenesulfinic acid sodium salt in the presence of 1-butyl-3-methyl imidazolium hydroxide ([bmim]OH) in EtOH under reflux. The ionic liquid was recovered and recycled for subsequent reactions. The advantages of this protocol were non-toxic, easy work-up and good yields.

The novel preparation of hydrocinnamonitriles via the reduction of α- phenylsulfonyl cinnamonitriles with SmI2/CH3OH/THF system

Hydrocinnamonitriles were readily obtained via the reduction of α- phenylsulfonyl cinnamonitriles by SmI2/CH3OH/THF system.