507231-47-2Relevant academic research and scientific papers
Synthesis of (Z)-α-chloro-α,β-unsaturated esters with complete stereoselectivity promoted by samarium diiodide
Concellón, José M.,Huerta, Mónica,Llavona, Ricardo
, p. 4665 - 4667 (2004)
Stereoselective β-elimination in α,α-dichloro-β- hydroxyesters 2 was achieved by using samarium diiodide, yielding (Z)-α-chloro-α,β-unsaturated esters 1. The starting compounds 2 were easily prepared by reaction of the lithium enolate of ethyl dichloroacetate with different aldehydes at -78°C. A mechanism to explain this process is proposed.
Synthesis of dihalohydrins and tri- and tetra-substituted olefins
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Page 9, (2008/06/13)
A novel synthesis reaction for highly stereospecific tri- and tetra-substituted olefins is described. A single stereoisomer of stable α-halo-α,β-ester is produced in high yield by the reaction of aldehyde or ketone with a trihalogenated compound such as t
(Z)-α-haloacrylates: An exceptionally stereoselective preparation via Cr(II)-mediated olefination of aldehydes with trihaloacetates
Barma,Kundu, Abhijit,Zhang, Hongming,Mioskowski, Charles,Falck
, p. 3218 - 3219 (2007/10/03)
(Z)-α-Fluoro-, (Z)-α-chloro-, and (Z)-α-bromoacrylates were obtained with unprecedented yield and stereocontrol (>99%) via addition of the corresponding commercial trihaloacetates to aldehydes at room temperature using stoichiometric Cr(II) salts or catal
