611-75-6Relevant articles and documents
Efficient production method of bromhexine hydrochloride
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Paragraph 0081; 0088-0093; 0099; 0103-0105; 0110; 0114-0116, (2021/01/28)
The invention belongs to the technical field of biological medicines, and particularly relates to an efficient production method of bromhexine hydrochloride. The production method of bromhexine hydrochloride comprises the following steps: (1) reducing 3,5-dibromo-2-aminobenzaldehyde by a reducing agent to obtain an intermediate 3,5-dibromo-2-aminobenzyl alcohol; (2) reacting the intermediate 3,5-dibromo-2-aminobenzyl alcohol with N-methylcyclohexylamine, and then carrying out salt forming reaction to obtain a bromhexine hydrochloride crude product; and (3) purifying the bromhexine hydrochloride crude product to obtain the bromhexine hydrochloride.
Preparation method of bromhexine hydrochloride
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Paragraph 0066-0079; 0088-0091, (2020/08/09)
The invention belongs to the field of pharmaceutical chemicals, and particularly relates to a bromhexine hydrochloride synthesis method. The synthesis method comprises following steps: step A, carrying out a reduction reaction between 2-amino-3,5-dibromobenzaldehyde and a reducing agent to generate 2-amino-3,5-dibromobenzyl alcohol; step B, reacting 2-amino-3,5-dibromobenzyl alcohol obtained in the step A with thionyl chloride to generate 2,4-bromo-6-chloromethyl aniline; and step C, carrying out an amination reaction between 2, 4-bromo-6-chloromethyl aniline obtained in the step B and N-methyl cyclohexyl amine, and then carrying out a salt forming reaction with an HCl salifying reagent to obtain bromhexine hydrochloride. According to the preparation method, thionyl chloride is only used as a reactant; in addition, the steps are simple, the intermediates obtained in the steps A and B do not need to be purified and directly used for the next step of reactions, therefore, the working hours required by the whole production route are remarkably shortened, the final yield is increased by 5% or above, and the method is particularly suitable for large-scale production.