50743-18-5Relevant articles and documents
An efficient one step conversion of 3-formylchromones into 3-cyanochromones
Jagath Reddy,Latha,Thirupathaiah,Srinivasa Rao
, p. 287 - 289 (2004)
-
KHMDS enhanced SmI2-mediated reformatsky type α-cyanation
Ankner, Tobias,Friden-Saxin, Maria,Pemberton, Nils,Seifert, Tina,Grotli, Morten,Luthman, Kristina,Hilmersson, Goeran
supporting information; experimental part, p. 2210 - 2213 (2010/08/04)
A novel combination of SmI2, KHMDS, and TsCN can be utilized to introduce a cyano group into structurally diverse and highly sensitive 2-alkyl-chroman-4-ones. Subsequent oxidation allows the formed 2-alkyl-3-cyanochromones to be isolated in yields ranging from 49 to 77%. In addition, α-bromoketones and esters were found to undergo equally effective α-cyanation.