50780-46-6

Upstream product

• 619-73-8 4-nitrobenzyl chloride 
• 22128-62-7 carbonochloridic acid, chloromethyl ester 

Downstream Products

• 88670-05-7 (3S,4R)-1-(tert-butyldimethylsilyl)-3-<(R)-1-((tert-butyldimethylsilyl)oxy)ethyl>-4-<2-oxo-3-(tert-butoxycarbonyl)-3-(1-(((((p-nitrobenzyl)oxy)carbonyl)oxy)methyl)tetrazol-5-yl)propyl>azetidin-2-one 
• 88685-62-5 Carbonic acid 5-{(5R,6S)-6-((R)-1-hydroxy-ethyl)-3-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-2-en-2-yl}-tetrazol-1-ylmethyl ester 4-nitro-benzyl ester 
• 88670-02-4 Trifluoro-methanesulfonic acid (5R,6S)-6-((R)-1-hydroxy-ethyl)-2-[1-(4-nitro-benzyloxycarbonyloxymethyl)-1H-tetrazol-5-yl]-7-oxo-1-aza-bicyclo[3.2.0]hept-2-en-3-yl ester 
• 88670-08-0 Carbonic acid 5-[(5R,6S)-3-(N,N-dimethyl-carbamimidoylmethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-en-2-yl]-tetrazol-1-ylmethyl ester 4-nitro-benzyl ester 
• 88669-95-8 Carbonic acid 5-[(5R,6S)-6-((R)-1-hydroxy-ethyl)-7-oxo-3-phenylsulfanyl-1-aza-bicyclo[3.2.0]hept-2-en-2-yl]-tetrazol-1-ylmethyl ester 4-nitro-benzyl ester 
• 88685-63-6 (3S,4R)-1-(tert-butyldimethylsilyl)-3-<(R)-1-hydroxyethyl>-4-<2-oxo-3-(5-(1-((((p-nitrobenzyl)oxy)carbonyl)oxy)methyl)tetrazolyl)propyl>azetidin-2-one 
• 88670-06-8 Carbonic acid 5-[(5R,6S)-3-(2-cyano-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-en-2-yl]-tetrazol-1-ylmethyl ester 4-nitro-benzyl ester 
• 88670-07-9 (5R,6S)-2-((cyanomethyl)thio)-6-<(R)-1-hydroxyethyl>-2-(1-((((p-nitrobenzyl)oxy)carbonyl)methyl)tetrazol-5-yl)-1-azabicyclo<3.2.0>hept-2-en-7-one 
• 88669-87-8 (3S,4R)-3-<(R)-1-hydroxyethyl>-4-<2-oxo-3-diazo-(1-(((((p-nitrobenzyl)oxy)carbonyl)oxy)methyl)tetrazol-5-yl)propyl>azetidin-2-one 
• 88669-85-6 (3S,4R)-3-<(R)-1-hydroxyethyl>-4-<2-oxo-3-(1-(((((p-nitrobenzyl)oxy)carbonyl)oxy)methyl)tetrazol-5-yl)propyl>azetidin-2-one 
• 88669-90-3 (5R,6S)-3,7-dioxo-6-<(R)-1-hydroxyethyl>-2-(1-(((((p-nitrobenzyl)oxy)carbonyl)oxy)methyl)tetrazol-5-yl)-1-azabicyclo<3.2.0>heptane 
• 88669-80-1 tert-butyl (2-(((((p-nitrobenzyl)oxy)carbonyl)oxy)methyl)tetrazol-5-yl)acetate 
• 88669-76-5 tert-butyl (1-(((((p-nitrobenzyl)oxy)carbonyl)oxy)methyl)tetrazol-5-yl)acetate 

Relevant academic research and scientific papers

Total Synthesis of 3-(5-Tetrazolyl)carbapenems

The synthesis of the title compounds, β-lactam antibiotics, is described.A new tetrazole protecting group, (((p-nitrobenzyl)carbonyl)oxy)methyl, was succesfully applied.Substitution of carboxyl by tetrazole on the carbapenem nucleus results in stability to a degradative renal enzyme.

6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-3-tetrazoly-1-carbadethiapen-2-em

Disclosed is the antibiotic 6-(1-hydroxyethyl)-2-substituted-thio-3-tetrazolyl-1-carbadethiapen-2-em and its pharmaceutically acceptable salts (I): STR1 wherein Z is C1 -C3 alkylamino, C1 -C3 alkylguanidino, Cs