Journal of the American Chemical Society p. 1808 - 1811 (1984)
Update date:2022-09-26
Topics:
Andrus, Alex
Heck, James V.
Christensen, Burton G.
Partridge, Beverly
The synthesis of the title compounds, β-lactam antibiotics, is described.A new tetrazole protecting group, (((p-nitrobenzyl)carbonyl)oxy)methyl, was succesfully applied.Substitution of carboxyl by tetrazole on the carbapenem nucleus results in stability to a degradative renal enzyme.
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