50790-26-6

Usage

Uses

Used in Pharmaceutical Industry:
Propanedioic acid, phenyl-2-propenyl-, diethyl ester is used as an intermediate in the synthesis of Alphenal, which is a Barbituric Acid (B118650) derivative. Alphenal possesses anti-convulsive properties and is classified as a controlled substance due to its potential for misuse and dependence.
As an intermediate in the synthesis of Alphenal, Propanedioic acid, phenyl-2-propenyl-, diethyl ester plays a crucial role in the development of medications aimed at treating convulsive disorders and other related conditions. Its involvement in the production of a controlled substance highlights the importance of its regulated use and the need for careful monitoring in the pharmaceutical industry.

Upstream product

• 28744-77-6 sodium diethyl-2-phenylmalonate 
• 106-95-6 allyl bromide 
• 83-13-6 diethyl 2-phenylmalonate 
• 101-97-3 Ethyl 2-phenylethanoate 
• 90-27-7 2-Phenylbutyric acid 
• 107-05-1 3-chloroprop-1-ene 
• 556-56-9 allyl iodid 

Downstream Products

• 109689-77-2 2-phenyl-pent-4-enoic acid-(2-piperidino-ethyl ester) 
• 1575-70-8 2-phenyl-pent-4-enoic acid 
• 19846-06-1 phenyl-propyl-malonic acid diethyl ester 
• 79835-78-2 5-allyl-5-phenyl-2-thio-barbituric acid 
• 13395-46-5 2-phenyl-pent-4-enoic acid-(2-diethylamino-ethyl ester) 
• 41921-35-1 2-Allyl-2-phenyl-propane-1,3-diol 
• 100519-19-5 allyl-phenyl-malonic acid 

Relevant academic research and scientific papers

Aryltrifluoromethylative cyclization of unactivated alkenes by the use of PhICF3Cl under catalyst-free conditions

A concise and catalyst-free aryltrifluoromethylative cyclization of unactivated alkenes has been developed herein. The use of PhICF3Cl as a powerful trifluoromethylating agent allows easy transformations. A set of trifluoroethylated carbocycles and aza-hereocycles were efficiently synthesized in good yield and selectivity. A broad substrate scope, mild reaction conditions, and easy operation would make this method well-suited for applications.

Isomerization of olefins triggered by rhodium-catalyzed C-H bond activation: Control of endocyclic β-hydrogen elimination

Five-membered metallacycles are typically reluctant to undergo endocyclic β-hydrogen elimination. The rhodium-catalyzed isomerization of 4-pentenals into 3-pentenals occurs through this elementary step and cleavage of two C-H bonds, as supported by deuterium-labeling studies. The reaction proceeds without decarbonylation, leads to trans olefins exclusively, and tolerates other olefins normally prone to isomerization. Endocyclic β-hydrogen elimination can also be controlled in an enantiodivergent reaction on a racemic mixture.

Pd-catalyzed α-allylation of 2-phenylpropanal and other carbonyl compounds with allyl alcohol and allyl acetates/carbonates in ionic liquids

The successful Pd-catalysed allylation of 2-phenylpropanal with allyl alcohol in ionic liquid is described and thus a simplier reaction composition catalytic system than in THF is possible. On the other hand, the Pd-catalyzed α-allylation of the same substrate with allyl acetate or allyl ethyl carbonate is proceeding nicely in ionic liquids. Allylation of different carbonyl derivatives was studied and it was found that the reaction is restricted to carbonyl derivatives from which a carbanion stabilized by an adjacent aromatic ring can be formed.

Catalytic deallylation of allyl- and diallylmalonates

Substituted allylmalonates undergo the selective C-C bond cleavage in the presence of triethylaluminum and a catalytic amount of nickel and ruthenium phosphine complexes, resulting in the loss of the allyl moiety and formation of monosubstituted malonates. Comparison of reactivity of the nickel and ruthenium complexes showed that the use of the former is general with respect to the structure of the substituted allylmalonates, and the activity of the latter depended on the substitution pattern of the double bond of the allylic moiety. The smooth deallylation may encourage the use of the allyl group as a protective group for the acidic hydrogen in malonates. Copyright

Insecticidal esters of substituted furan methanol

Substituted acetate compounds represented by the formula STR1 which are useful as pesticides and pesticidal composition containing the substituted acetate compounds as active ingredients, as well as processes for preparing the compounds and the compositio