50838-36-3 Usage
Originator
Tolmicen,Carlo Erba,Italy,1979
Manufacturing Process
Thiophosgene (1.15 g, 0.01 mol) in chloroform (40 ml) was slowly treated at
room temperature with sodium 1,4-methano-1,2,3,4-tetrahydro-6-
naphthoxide (1.82 g, 0.01 mol). After 30 minutes, N-methyl-m-toluidine (2.42
g, 0.02 mol) in chloroform (40 ml) was added dropwise to the solution so
obtained at room temperature. The reaction mixture was stirred for 48 hours
at room temperature and then refluxed for 2 hours. The solvent was
evaporated, and the residue redissolved in water and extracted repeatedly
with diethyl ether. The organic phase was dried (Na2SO4) and evaporated to dryness to give, after crystallization from isopropanol, O-(1,4-methano-
1,2,3,4-tetrahydro-6-naphthyl)-N-methyl-N-(m-tolyl)-thiocarbamate (1.3 g)
melting point 92°C to 94°C.
Therapeutic Function
Topical antimycotic
Check Digit Verification of cas no
The CAS Registry Mumber 50838-36-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,8,3 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 50838-36:
(7*5)+(6*0)+(5*8)+(4*3)+(3*8)+(2*3)+(1*6)=123
123 % 10 = 3
So 50838-36-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H21NOS/c1-13-4-3-5-16(10-13)21(2)20(23)22-17-8-9-18-14-6-7-15(11-14)19(18)12-17/h3-5,8-10,12,14-15H,6-7,11H2,1-2H3
50838-36-3Relevant academic research and scientific papers
Synthesis of Bridged Cyclopentane Derivatives by Catalytic Decarbonylative Cycloaddition of Cyclobutanones and Olefins
Zhou, Xuan,Ko, Haye Min,Dong, Guangbin
, p. 13867 - 13871 (2016/10/26)
Herein, we report an intramolecular rhodium-catalyzed decarbonylative coupling between cyclobutanones and alkenes that proceeds by C?C activation and provides a distinct approach to a diverse range of saturated bridged cyclopentane derivatives. In this reaction, cyclobutanones serve as cyclopropane surrogates, reacting in a formal (4+2?1) transformation. To demonstrate the efficacy of this method, it was applied in a concise synthesis of the antifungal drug Tolciclate.
