50866-75-6

Basic information

• Product Name: 1-(1-PENTYL)PIPERAZINE
• Synonyms: Piperazine, 1-pentyl- (6CI,9CI);1-PENTYLPIPERAZINE;1-pentylpiperazine(SALTDATA: FREE);1-(Pent-1-yl)piperazine;1-amylpiperazine;1-(1-PENTYL)PIPERAZINE;RARECHEM AH CK 0148;1-(1-PENTYL)-PIPERAZINE >98%
• CAS NO: 50866-75-6
• Molecular Formula: C₉H₂₀N₂
• Molecular Weight: 156.27
• Product Categories: PIPERIDINE;piperazines
• Mol File: 50866-75-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 88-91°C/20mm
• Flash Point: 73.6 °C
• Appearance: /
• Density: 0.865 g/cm³
• Vapor Pressure: 0.138mmHg at 25°C
• Refractive Index: 1.45
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.32±0.10(Predicted)
• CAS DataBase Reference: 1-(1-PENTYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-PENTYL)PIPERAZINE(50866-75-6)
• EPA Substance Registry System: 1-(1-PENTYL)PIPERAZINE(50866-75-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 50866-75-6(Hazardous Substances Data)

Usage

General Description

1-(1-Pentyl)piperazine, also known as 1-PP, is a chemical compound that belongs to the class of piperazines. It is a psychoactive substance that acts as a designer drug and is often used in recreational settings for its euphoric and stimulant effects. 1-(1-Pentyl)piperazine is commonly found in illegal drug products sold under street names such as "Legal X" or "A3A." The substance is known for its potential for abuse and has been associated with a range of adverse health effects, including hallucinations, paranoia, and cardiovascular complications. Due to its psychoactive properties and potential for harm, 1-(1-Pentyl)piperazine is considered a controlled substance in many jurisdictions and is subject to legal restrictions.

InChI:InChI=1/C9H20N2/c1-2-3-4-7-11-8-5-10-6-9-11/h10H,2-9H2,1H3

Upstream product

• 110-85-0 piperazine 
• 628-17-1 amyl iodide 
• 110-53-2 1-Bromopentane 

Downstream Products

• 1245316-89-5 2-(4-fluorophenyl)-7-(4-pentylpiperazin-1-yl)thiazolo[5,4-d]pyrimidin-5-amine 
• 129664-02-4 4-Pentyloxy-2-(4-pentyl-piperazin-1-yl)-quinazoline; compound with (E)-but-2-enedioic acid 
• 77777-05-0 8-Benzylthio-4-morpholino-2-(N-pentyl-piperazino)-pyrimido-[5,4-d]-pyrimidine 

Relevant articles and documents

Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents

The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence and rise of azole-resistant fungi. The fungistatic nature of FLC in combination with toxicity concerns have resulted in an increased demand for new azole antifungal agents. Herein, we report the synthesis and antifungal activity of novel alkylated piperazines and alkylated piperazine-azole hybrids, their time-kill studies, their hemolytic activity against murine erythrocytes, as well as their cytotoxicity against mammalian cells. Many of these molecules exhibited broad-spectrum activity against all tested fungal strains, with excellent minimum inhibitory concentration (MIC) values against non-albicans Candida and Aspergillus strains. The most promising compounds were found to be less hemolytic than the FDA-approved antifungal agent voriconazole (VOR). Finally, we demonstrate that the synthetic alkylated piperazine-azole hybrids do not function by fungal membrane disruption, but instead by disruption of the ergosterol biosynthetic pathway via inhibition of the 14α-demethylase enzyme present in fungal cells.

Potential antiarrhythmic agents. I. Synthesis and pharmacological evaluation of some piperazine and ethylenediamine analogs of procaine amide.

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