50868-76-3

Upstream product

• 77774-35-7 N-(2-hydroxy-6-methylphenyl)acetamide 
• 77-78-1 dimethyl sulfate 
• 50868-73-0 2-methoxy-6-methylbenzeneamine 
• 5345-42-6 1-methoxy-3-methyl-2-nitro-benzene 
• 108-24-7 acetic anhydride 
• 4920-77-8 3-methyl-2-nitrophenol 
• 2835-97-4 2-amino-3-methylphenol 
• 75-36-5 acetyl chloride 
• 93-26-5 2-methoxyacetanilide 
• 100-84-5 1-methoxy-3-methyl-benzene 
• 861304-52-1 5-methoxy-6-nitro-toluene-2,4-disulfonyl chloride 
• 861304-53-2 6-methyl-4-methoxy-1,3-benzenedisulfonyl chloride 

Downstream Products

• 133841-05-1 7-methoxy-1H-indazole 
• 68701-23-5 2-amino-3-methoxybenzoic acid hydrochloride 
• 35214-99-4 8-methoxydeoxyvasicinone 
• 81382-46-9 7-hydroxy-1H-indazole 
• 1266338-97-9 N-(2-methoxy-6-methyl-4-(N-(phenylsulfonyl)phenylsufonamido)phenyl)acetamide 
• 73568-28-2 2-chloro-8-methoxyquinoline-3-carbaldehyde 

Relevant academic research and scientific papers

Synthesis of indenoquinolinone through aryne-mediated Pd(II)-catalysed remote C–H activation

Abstract: [Figure not available: see fulltext.]Indenoquinolinones have been synthesized from 2-haloquinoline-3-carbaldehyde through Pd-mediated simultaneous C–H (aldehyde) and C–X bond activation. DFT studies were performed to investigate the mechanistic pathway, and in situ UV–Vis studies indicate the presence of Pd(II) intermediate species. Aryne ligated Pd complex is actual intermediate in these reactions. Ligation of reactive aryne to Pd reduces probability of side reactions. Graphic abstract: [Figure not available: see fulltext.]

Mild palladium-catalyzed C-H alkylation using potassium alkyltrifluoroborates in combination with MnF3

A Pd-catalyzed method for ligand-directed C-H alkylation with organoboron reagents is described. The combination of potassium organotrifluoroborates, MnF3, and a PdII catalyst effects pyridine and amide-directed C-H alkylation. These reactions proceed under mild conditions (25-40 C in weakly acidic media), are effective for installing methyl and 1 alkyl groups, and do not require promoters such as benzoquinone.

Palladium-catalyzed C-H aminations of anilides with N - fluorobenzenesulfonimide

The first amide-directed, palladium-catalyzed, intermolecular, highly selective C-H aminations with the non-nitrene-based nitrogen source N-fluorobenzenesulfonimide have been developed. This methodology might provide a new pathway for directed metal-catalyzed aromatic C-H amination.

INDOLE, INDAZOLE, AND BENZAZOLE DERIVATIVE

The compound of the formula (I): wherein W is a group of the following formula (VIII) binding to any possible position on the Q: Q is, together with W, a group of the formula: -C(M=C(R3A)-N(R3)-, etc.; R3A is H or optionally substituted lower alkyl; R4, R5, R6, and R7 are independently H or optionally substituted lower alkyl; R1 is optionally substituted lower alkyl, etc.; R2 is H, etc.; R3 is H, etc.; Ar is phenyl, etc., or a pharmaceutically acceptable salt thereof, where these compounds exhibiting β3-adrenoceptor-stimulating activity and being useful as a medicament for treatment of obesity, etc.

SYNTHETIC ANALOGS OF Peganum ALKALOIDS. I. SYNTHESIS OF METHOXY- AND HYDROXY-SUBSTITUTED DEOXYVASICINONES AND DEOXYPEGANINES

6-Methoxy-, 7-methoxy-, and 8-methoxydeoxyvasicinones have been synthesized by the reaction of substituted (3-methoxy-, 4-methoxy-, and 5-methoxy-) anthranilic acids with α-pyrrolidone.The demethylation of these compounds has given the corresponding hydroxy-substituted analogs of deoxyvasicinone, and the reduction of the products obtained with zinc in hydrochloric acid has given the hydroxy- and methoxy- analogs of deoxypeganine. 8-Hydrooxydeoxypeganine dimethyl-, ethyl-, and butylcarbamates have been obtained by the carbamoylation of 8-hydroxydeoxypeganine.