81382-46-9 Usage
Description
1H-Indazol-7-ol, also known as 7-Hydroxyindazole, is a heterocyclic aromatic compound with the molecular formula C7H6N2O. It is a derivative of indazole and has applications in organic synthesis, pharmaceuticals, and research due to its potential biological and medicinal properties.
Uses
Used in Organic Synthesis:
1H-Indazol-7-ol is used as a building block for the preparation of various pharmaceuticals and other organic compounds. Its unique structure and functional groups make it a versatile intermediate in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
1H-Indazol-7-ol is being studied for its potential biological and medicinal properties, including its anti-inflammatory and antioxidant effects. Its presence in pharmaceuticals can contribute to the development of new drugs with improved therapeutic effects.
Used in Research and Development:
1H-Indazol-7-ol has been identified as a potential intermediate in the production of novel chemical compounds for use in industry and research. Its exploration in research settings can lead to the discovery of new applications and advancements in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 81382-46-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,3,8 and 2 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 81382-46:
(7*8)+(6*1)+(5*3)+(4*8)+(3*2)+(2*4)+(1*6)=129
129 % 10 = 9
So 81382-46-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H6N2O/c10-6-3-1-2-5-4-8-9-7(5)6/h1-4,10H,(H,8,9)
81382-46-9Relevant articles and documents
Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: Particular potency of 1H-indazole-7-carbonitrile
Cottyn, Betty,Acher, Francine,Ramassamy, Booma,Alvey, Luke,Lepoivre, Michel,Frapart, Yves,Stuehr, Dennis,Mansuy, Daniel,Boucher, Jean-Luc,Vichard, Dominique
, p. 5962 - 5973 (2008/12/23)
A series of new 7-monosubstituted and 3,7-disubstituted indazoles have been prepared and evaluated as inhibitors of nitric oxide synthases (NOS). 1H-Indazole-7-carbonitrile (6) was found equipotent to 7-nitro-1H-indazole (1) and demonstrated preference for constitutive NOS over inducible NOS. By contrast, 1H-indazole-7-carboxamide (8) was slightly less potent but demonstrated a surprising selectivity for the neuronal NOS. Further substitution of 6 by a Br-atom at carbon-3 of the heterocycle enhanced 10-fold the inhibitory effects. Inhibition of NO formation by 6 appeared to be competitive versus both substrate and the cofactor (6R)-5,6,7,8-tetrahydro-l-biopterin (H4B). In close analogies with 1, compound 6 strongly inhibited the NADPH oxidase activity of nNOS and induced a spin state transition of the heme-FeIII. Our results are explained with the help of the X-ray structures that identified key-features for binding of 1 at the active site of NOS.