50901-80-9

Upstream product

• 23784-45-4 N-ethyl-cinnamamide 
• 27829-46-5 N,N-diethylcinnamide 
• 1400888-66-5 (3R)-4-nitro-3-phenylpentanoic acid 
• 1400888-72-3 methyl erythro-(3R,4S)-4-nitro-3-phenylpentanoate 
• 1301211-81-3 diethyl (1R)-2-(2-nitro-1-phenylpropyl)malonate 
• 27845-85-8 (E)-N-ethyl-3-phenyl-2-propenamide 
• 1400888-68-7 methyl threo-(3R,4R)-4-nitro-3-phenylpentanoate 
• 1400888-67-6 methyl 4-nitro-3(R)-phenylpentanoate 
• 705-60-2 (2-nitroprop-1-enyl)benzene 
• 96013-62-6 5-methyl-1-tosyl-1,5-dihydro-2H-pyrrol-2-one 
• 1301211-88-0 ethyl (5S)-methyl-(4R)-phenyl-2-pyrrolidinone-(3S)-carboxylate 
• 96013-63-7 (4R,5R)-5-Methyl-4-phenyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-one 

Downstream Products

• 1424832-60-9 C₁₃H₁₆N₂O₂ 
• 1431790-48-5 ethyl erythro-(4S,5R)-2-(5-methyl-4-phenylpyrrolidin-1-yl)acetate 
• 1301211-93-7 ethyl erythro-(4R,5S)-2-(5-methyl-4-phenylpyrrolidin-1-yl)acetate 
• 1301211-78-8 (4R,5S)-2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)acetamide 
• 1400888-70-1 ethyl threo-(4R,5R)-2-(5-methyl-4-phenylpyrrolidin-1-yl)acetate 
• 1400888-63-2 2-[5(R)-methyl-2-oxo-4(R)-phenyl-pyrrolidin-1-yl]-acetamide 
• 92146-93-5 4-Amino-3-phenyl-valeriansaeure 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2- oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor

Novel positive allosteric modulators of sigma-1 receptor represented by 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide enantiomers were synthesised using an asymmetric Michael addition of 2-nitroprop-1-enylbenzene to diethyl malonate. Following the

4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY

The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrroli

4R,5R-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY

The invention relates to the 5R,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl- pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method.

4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY

The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl- pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrol

Catalytic asymmetric conjugate addition of nitroalkanes to 4-nitro5-styrylisoxazoles

(Chemical equation presented) Nitro versus nitro: 4-Nitro-5- styrylisoxazoles were used as masked α,β-unsaturated carboxylic acids in the titled catalytic asymmetric transformation. The 4-nitroisoxazole core acts as an activator of the conjugated alkene and a latent carboxylate functionality. The reaction proceeded with 5 mol% of a readily prepared phasetransfer catalyst at room temperature with remarkable diastereo- and enantioselectivity (see scheme).

Cyclisation at very high temperature. Thermal transformations of N-alkyl and N, N-dialkyl amides of α,β-unsaturated acids into mono- and bicyclic heterocycles under FVT conditions

Cyclisations of N-alkyl and N,N-dialkyl cinnamic amides to the corresponding pyrrolidin-2-ones under the conditions of flash vacuum thermolysis (FVT), are described. It was found that these reactions proceed at 950-1000 °C affording in various yields the

Cyclisation at very high temperature. Thermal transformations of N-alkyl and N,N-dialkyl cinnamic amides into pyrrolidin-2-ones under FVT conditions

Novel cyclisations of N-alkyl and N,N-dialkyl cinnamic amides to the corresponding pyrrolidin-2-ones under the conditions of flash vacuum thermolysis, are described. It was found that this reaction proceeds at 950-1000°C affording a mixture of isomeric pyrrolidin-2-ones in various yields. Two possible mechanisms are proposed for the process.

CONJUGATE ADDITION OF ORGANOCOPPER REAGENTS TO N-TOSYLATED α, β-UNSATURATED AMIDES

N-Tosylated α, β-unsaturated amides and lactams undergo facile conjugate addition with R2CuLi or RMgX/CuI (cat.).Stereoselective synthesis of trans-β,γ-dialkyl-γ-lactams can be achieved by this procedure.The resulting N-tosylamide moiety is further transformed to alcohol and several carbonyl compounds by way of reduction or nucleophillic displacement.