509089-07-0

Upstream product

• 15570-12-4 3-methoxybenzenethiol 
• 84194-36-5 2-chloro-4-fluorobenzaldehyde 

Downstream Products

• 1618092-58-2 (2R)-2-amino-4-{2-chloro-4-[(3-methoxyphenyl)sulfanyl]phenyl}-2-methyl-butan-1-ol 
• 1618092-56-0 (4R)-4-[(E)-2-{2-chloro-4-[(3-methoxyphenyl)sulfanyl]phenyl}ethenyl]-4-methyl-1,3-oxazolidin-2-one 
• 1618092-57-1 (4R)-4-(2-{2-chloro-4-[(3-methoxyphenyl)sulfanyl]phenyl}ethyl)-4-methyl-1,3-oxazolidin-2-one 

Relevant academic research and scientific papers

Synthesis of a chiral phosphonium salt for the preparation of α-substituted alaninol derivatives

We herein report the synthesis of a chiral phosphonium salt, {[(4S)-4-methyl-2-oxo-1,3-oxazolidin-4-yl]methyl}(triphenyl)phosphonium iodide 13 to provide a new Wittig reagent for the general method of synthesizing α-substituted alaninol derivatives. Our method described here is widely applicable to reactions with various types of aldehyde to afford olefin products with high E-selectivity, enabling us to provide a new approach to the synthesis of chiral S1P1agonists including our key intermediates, and of the trace amine-associated receptor 1 (TAAR1) agonist.

Synthesis of a chiral phosphonium salt for the preparation of α-substituted alaninol derivatives

We herein report the synthesis of a chiral phosphonium salt, {[(4S)-4-methyl-2-oxo-1,3-oxazolidin-4-yl]methyl}(triphenyl)phosphonium iodide 13 to provide a new Wittig reagent for the general method of synthesizing α-substituted alaninol derivatives. Our method described here is widely applicable to reactions with various types of aldehyde to afford olefin products with high E-selectivity, enabling us to provide a new approach to the synthesis of chiral S1P1 agonists including our key intermediates, and of the trace amine-associated receptor 1 (TAAR1) agonist.

AMINO ALCOHOL DERIVATIVE, ADDITION SALT THEREOF, AND IMMUNOSUPPRESSANT

An amino alcohol derivative represented by the following general formula (1) (for example, (±)-2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentane-1-ol) exhibits strong immunosuppressive effect while causing less side effects:

AMINOPHOSPHONIC ACID DERIVATIVES, ADDITION SALTS THEREOF AND S1P RECEPTOR MODULATORS

Aminophosphonic acid derivatives (e.g., 2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentylphosphonate monoester) are represented by the following general formula (1) : and act as effective S1P receptor modulators while posing less side effects.

DIARYL SULFIDE DERIVATIVE, ADDITION SALT THEREOF, AND IMMUNOSUPPRESSANT

The present invention provides diaryl sulfide derivatives that exhibit significant immunosuppressive effects with less side effects. The diaryl derivatives of the present invention are represented by the following general formula (1): One example is 2-ami