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5097-86-9

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5097-86-9 Usage

General Description

4-(4-chlorophenyl)-1H-1,2,4-triazol-5(4H)-one is a chemical compound with the molecular formula C9H6ClN3O. It is a white crystalline powder with a molecular weight of 207.613 g/mol. 4-(4-Chlorophenyl)-1H-1,2,4-triazol-5(4H)-one is used in the field of pharmaceuticals as it exhibits antifungal properties and is commonly used in the treatment of fungal infections. It works by inhibiting the enzyme cytochrome P450 14α-demethylase, which is essential for the synthesis of ergosterol, an important component of fungal cell membranes. This disruption in membrane integrity leads to the death of the fungal cells, thereby treating the infection. The compound has also been studied for its potential use as an anti-tumor and anti-inflammatory agent.

Check Digit Verification of cas no

The CAS Registry Mumber 5097-86-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,0,9 and 7 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5097-86:
(6*5)+(5*0)+(4*9)+(3*7)+(2*8)+(1*6)=109
109 % 10 = 9
So 5097-86-9 is a valid CAS Registry Number.

5097-86-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(4-Chlorophenyl)-1H-1,2,4-triazol-5(4H)-one

1.2 Other means of identification

Product number -
Other names 4-(4-chlorophenyl)-1H-1,2,4-triazol-5-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5097-86-9 SDS

5097-86-9Relevant articles and documents

GPR139 RECEPTOR MODULATORS

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Page/Page column 62; 63, (2021/06/26)

Compounds are provided that modulate the GPR139 receptor, compositions containing the same, and to methods of their preparation and use for treatment of a malcondition wherein modulation of the GPR139 receptor is medically indicated or beneficial. Such compounds have the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R1, R4, R5, R9, R10, Q6, Q7, and Q12 are as defined herein.

Design, synthesis and antifungal evaluation of 1-(2-(2,4-difluorophenyl)-2- hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one

Jiang, Yongwei,Cao, Yongbin,Zhang, Jun,Zou, Yan,Chai, Xiaoyun,Hu, Honggang,Zhao, Qingjie,Wu, Qiuye,Zhang, Dazhi,Jiang, Yuanying,Sun, Qingyan

experimental part, p. 3135 - 3141 (2011/07/08)

Based on the structure of the active site of cytochrome P450 14α-demethylase (CYP51) and the conclusions of the structure-activity relationships of azole antifungals, a series of 1-(2-(2,4-difluoro-phenyl)-2- hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one of fluconazole analogs was synthesized. All compounds were characterized by IR, HRMS, 1HNMR and 13C NMR spectroscopic analysis. Results of preliminary antifungal in vitro test using eight human pathogenic species showed that some compounds displayed comparable or even better antifungal activities than reference drug fluconazole and that compound 3i exhibited significant activity against Candida albicans being worthy of further optimization.

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