51-73-0

Usage

Uses

Used in Neuroscience Research:
1 1-(2-Butynylene)dipyrrolidine dihydrochloride 97% is used as a research tool for studying the function and modulation of the α7 nicotinic acetylcholine receptor (nAChR). It aids in understanding the receptor's role in various physiological and pathological processes in the central nervous system.
Used in Studying Neurological Disorders:
1 1-(2-Butynylene)dipyrrolidine dihydrochloride 97% is used as a research compound to investigate the underlying mechanisms of neurological disorders associated with the α7 nAChR. This helps in gaining insights into the development of potential therapeutic agents targeting the receptor.
Used in Drug Development:
1 1-(2-Butynylene)dipyrrolidine dihydrochloride 97% is utilized in the development of potential therapeutic agents targeting the α7 nicotinic acetylcholine receptor (nAChR). Its high purity and agonist properties make it a valuable compound for creating new treatments for neurological disorders.

Upstream product

• 123-75-1 pyrrolidine 
• 821-10-3 1,4-Dichloro-2-butyne 
• 50-00-0 formaldehyd 
• 74-86-2 acetylene 
• 75-20-7 calcium carbide 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 109474-08-0 1,1'-dimethyl-1,1'-but-2-ynediyl-bis-pyrrolidinium; diiodide 
• 86336-59-6 2,5-dipyrrolidino-adiponitrile 
• 86178-55-4 1c,4t-dipyrrolidino-buta-1,3-diene 

Relevant academic research and scientific papers

N-Propargylation of secondary amines directly using calcium carbide as an acetylene source

A one-pot N-propargylation of secondary amines has been achieved by heating the amine with formaldehyde and calcium carbide in DMSO in the presence of CuCl as a catalyst. Fifteen examples of propargylic tertiary amines, 12 of which are novel, were efficiently prepared in yields of 65-84%. The advantages of the method are broad substrate scope and a simple work-up procedure.

Preparation of Tremorine and Gemini Surfactant Precursors with Cationic Ethynyl-Bridged Digold Catalysts

Tremorine and precursors of gemini surfactants were synthesised in a one-pot, three-step, double-catalytic A3coupling reaction and characterised by structural and spectroscopic methods. The cationic [AuI(L1)]SbF6complex is a more active catalyst compared to neutral L2– and L3–AuIbis(trifluoromethanesulfonyl)imidate complexes (L1, L2=Buchwald-type biaryl phosphane; L3=triphenylphosphine) in promoting the double A3coupling of ethynyltrimethylsilane, secondary amines (cyclic, aliphatic, or aromatic) and formaldehyde. The solvent influences the catalytic performance by desilylation of silyl acetylene or deactivation of the catalyst by a halide anion. Acetylide-bridged cationic digold(I) L1 and L2 complexes were isolated and characterised by means of single-crystal X-ray structure analysis and their spectroscopic properties. Iodine in the acetylene reagent deactivates the AuIcatalyst by formation of the less active iodido-bridged cationic digold(I) L1 complex, which was fully characterised by single-crystal X-ray crystal structure analysis and spectroscopy. The nature of the phosphine ligand of the gold complexes used as catalyst affects the stability and activity of the formed cationic ethynyl-bridged AuI2–L intermediates, isolation of which lends support to the proposed double A3coupling mechanism.