51023-59-7Relevant academic research and scientific papers
Enantioselective α-hydroxylation of β-keto esters catalyzed by chiral S-timolol derivatives
Cai, Yuanchun,Lian, Mingming,Li, Zhi,Meng, Qingwei
, p. 7973 - 7977 (2012/09/21)
A screen of aryloxy aminopropanol organocatalysts derived from the β-blocker inhibitor S-timolol determined the most active catalyst of asymmetric α-hydroxylation of β-keto esters. (R)-1-(tert-butylamino)- 3-(3,4,5-trimethoxyphenoxy) propan-2-ol (3k) was the most effective derivative, enantioselectively catalyzing α-hydroxylation of β-keto esters using tert-butyl hydroperoxide as the oxidant in hexane to afford the corresponding products in excellent yield and with good enantioselectivity (up to 96% yield, 88% ee).
