5106-48-9

Usage

Chemical structure

A synthetic steroid hormone derived from progesterone.

Common uses

Treatment of hormonal imbalances, irregular menstrual cycles, endometriosis, and certain types of cancer.

Anti-inflammatory properties

Potent anti-inflammatory effects.

Immunosuppressive properties

Potent immunosuppressive effects, useful in autoimmune conditions and organ transplant recipients.

Additional uses

Ingredient in some contraceptive pills and hormone replacement therapies.

Administration methods

Oral or through injection.

Monitoring

Requires careful monitoring due to potential side effects.

Side effects

Fluid retention, high blood pressure, and risk of blood clots.

InChI:InChI=1/C23H30O4/c1-14(24)23(27-15(2)25)12-9-20-18-6-5-16-13-17(26)7-10-21(16,3)19(18)8-11-22(20,23)4/h8,13,18,20H,5-7,9-12H2,1-4H3/t18-,20+,21+,22+,23+/m1/s1

Upstream product

• 34184-82-2 pregna-4,9⁽¹¹⁾-diene-3,20-dione-17-hydroxy-21-methyl 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 75868-48-3 21-chloro-17-hydroxy-pregna-4,9⁽¹¹⁾-diene-3,20-dione 
• 603-98-5 11α,17α-dihydroxypregn-4-ene-3,20-dione 
• 34184-82-2 17α-hydroxyandrost-4,9-diene-3,20-dione 

Downstream Products

• 2529-45-5 fluorogestone acetate 
• 24320-15-8 17-acetoxy-9-bromo-11β-hydroxy-pregn-4-ene-3,20-dione 

Relevant academic research and scientific papers

Fluorometholone, fluorometholone acetate, and preparation method thereof

The invention discloses fluorometholone, fluorometholone acetate, and a preparation method thereof. According to the preparation method, a compound represented by a formula (II) is taken as a raw material, the compound carries out de-chlorination reaction, esterification reaction, methenylation reaction, hydrogenation reaction, fermentation de-hydrogenation reaction, epoxidation reaction, and ring-opening reaction in sequence to obtain derivatives of fluorometholone; and fluorometholone derivatives carry out hydrolysis to obtain fluorometholone. The preparation method has the advantages of short synthesis route, high yield, low raw material cost, easily available raw materials, simple and convenient purification, high product purity, and strong technological operability, is suitable for industrial production, and has a high industrialization value.

Preparation method of 17alpha-acetoxy-(8, 13)-ene-11alpha-hydroxyprogesterone

The invention relates to the field of compound preparation, in particular to a preparation method of 17alpha-acetoxy-(8, 13)-ene-11alpha-hydroxyprogesterone. The method includes: taking 11alpha, 17alpha-dihydroxyprogesterone as the raw material, carrying out elimination reaction, esterification reaction, bromination epoxy reaction and fluorination reaction to synthesize a 17alpha-acetoxy-(8, 13)-ene-11alpha-hydroxyprogesterone crude product; and finally performing column chromatography to obtain the high purity target object 17alpha-acetoxy-(8, 13)-ene-11alpha-hydroxyprogesterone refined product. The invention mainly solves the problem that the existing technology is short of synthesis method of the product, the product can be used as a reference substance for quality control of flurogestone acetate, is more beneficial to control of the flurogestone acetate quality and improvement of the drug safety.

Method for synthesizing flurogestone acetate

The invention relates to the field of medicament synthesis, and discloses a method for synthesizing flurogestone acetate. The method is characterized by comprising the following steps: (1) synthesis of FPA-3; (2) synthesis of FPA-4; (3) synthesis of FPA-5; (4) synthesis of FPA-6. The method has the advantages of short synthesis route, low synthesis cost and high process controllability, and higher yield and purity of a prepared product.

PROCESS FOR OBTAINING FLUOROMETHOLONE AND INTERMEDIATES THEREFOR

The present invention relates to a process for obtaining compounds of formula (I) and (V), wherein R1 is C1-C6 alkyl; and R2 is OR3, OC(=O)R4 or O-(HPG), wherein R3 is H, C1-C6 alkyl or C6-C14 aryl; R4 is H or C1-C6 alkyl; and HPG is a hydro xyl protecting group, intermediates useful in the synthesis of some steroids, for example, fluorometholone and derivatives thereof. The invention also relates to other intermediates useful in synthesis.