5106-48-9

Basic information

• Product Name: 17-hydroxypregna-4,9(11)-diene-3,20-dione 17-acetate
• Synonyms: 17-hydroxypregna-4,9(11)-diene-3,20-dione 17-acetate;17-(Acetyloxy)pregna-4,9(11)-diene-3,20-dione;Einecs 225-828-1;Pregna-4,9(11)-diene-3,20-dione, 17-hydroxy-, acetate
• CAS NO: 5106-48-9
• Molecular Formula: C₂₃H₃₀O₄
• Molecular Weight: 370.4819
• EINECS: 225-828-1
• Mol File: 5106-48-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 502.8°Cat760mmHg
• Flash Point: 217.8°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 3.08E-10mmHg at 25°C
• Refractive Index: 1.556
• CAS DataBase Reference: 17-hydroxypregna-4,9(11)-diene-3,20-dione 17-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 17-hydroxypregna-4,9(11)-diene-3,20-dione 17-acetate(5106-48-9)
• EPA Substance Registry System: 17-hydroxypregna-4,9(11)-diene-3,20-dione 17-acetate(5106-48-9)

Safety Data

• Hazardous Substances Data: 5106-48-9(Hazardous Substances Data)

Usage

Chemical structure

A synthetic steroid hormone derived from progesterone.

Common uses

Treatment of hormonal imbalances, irregular menstrual cycles, endometriosis, and certain types of cancer.

Anti-inflammatory properties

Potent anti-inflammatory effects.

Immunosuppressive properties

Potent immunosuppressive effects, useful in autoimmune conditions and organ transplant recipients.

Additional uses

Ingredient in some contraceptive pills and hormone replacement therapies.

Administration methods

Oral or through injection.

Monitoring

Requires careful monitoring due to potential side effects.

Side effects

Fluid retention, high blood pressure, and risk of blood clots.

InChI:InChI=1/C23H30O4/c1-14(24)23(27-15(2)25)12-9-20-18-6-5-16-13-17(26)7-10-21(16,3)19(18)8-11-22(20,23)4/h8,13,18,20H,5-7,9-12H2,1-4H3/t18-,20+,21+,22+,23+/m1/s1

Upstream product

• 34184-82-2 17α-hydroxyandrost-4,9-diene-3,20-dione 
• 108-24-7 acetic anhydride 
• 75868-48-3 21-chloro-17-hydroxy-pregna-4,9⁽¹¹⁾-diene-3,20-dione 
• 34184-82-2 pregna-4,9⁽¹¹⁾-diene-3,20-dione-17-hydroxy-21-methyl 
• 603-98-5 11α,17α-dihydroxypregn-4-ene-3,20-dione 
• 64-19-7 acetic acid 

Downstream Products

• 24320-15-8 17-acetoxy-9-bromo-11β-hydroxy-pregn-4-ene-3,20-dione 
• 2529-45-5 fluorogestone acetate 

Relevant articles and documents

Fluorometholone, fluorometholone acetate, and preparation method thereof

The invention discloses fluorometholone, fluorometholone acetate, and a preparation method thereof. According to the preparation method, a compound represented by a formula (II) is taken as a raw material, the compound carries out de-chlorination reaction, esterification reaction, methenylation reaction, hydrogenation reaction, fermentation de-hydrogenation reaction, epoxidation reaction, and ring-opening reaction in sequence to obtain derivatives of fluorometholone; and fluorometholone derivatives carry out hydrolysis to obtain fluorometholone. The preparation method has the advantages of short synthesis route, high yield, low raw material cost, easily available raw materials, simple and convenient purification, high product purity, and strong technological operability, is suitable for industrial production, and has a high industrialization value.

Method for synthesizing flurogestone acetate

The invention relates to the field of medicament synthesis, and discloses a method for synthesizing flurogestone acetate. The method is characterized by comprising the following steps: (1) synthesis of FPA-3; (2) synthesis of FPA-4; (3) synthesis of FPA-5; (4) synthesis of FPA-6. The method has the advantages of short synthesis route, low synthesis cost and high process controllability, and higher yield and purity of a prepared product.