51069-84-2Relevant articles and documents
Synthesis and anti-inflammatory activity of 2-oxo-2H-chromenyl and 2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates
Bhimapaka, China Raju,Karri, Shailaja,Kuncha, Madhusudana,Kurma, Siva Hariprasad,Sistla, Ramakrishna
supporting information, (2020/06/22)
Cycloaddition reaction of 4-chloro-2-oxo-2H-chromene-3-carbaldehydes (3a-g) and 4-chloro-2H-chromene-3-carbaldehydes (7a-h) with activated alkynes (4a-b) provided the 2-oxo-2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates (5a-n) and 2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates (8a-p). All the prepared compounds were screened for anti-inflammatory activity. In vitro anti-inflammatory activity data demonstrated that the compounds 5g, 5i, 5k-l and 8f are effective among the tested compounds against TNF-α (1.108 ± 0.002, 0.423 ± 0.022, 0.047 ± 0.001, 0.070 ± 0.002 and 0.142 ± 0.001 μM) in comparison with standard compound Prednisolone (0.033 ± 0.002 μM). Based on in vitro results, three compounds (5i, 5k and 8f) have been selected for in vivo experiments and these compounds are identified as better compounds with respect to anti-inflammatory activity in LPS induced mice model. Compound 5i was identified as potent and showed significant reduction in TNF-α and IL-6.
Synthesis, anticancer activity and photophysical properties of novel substituted 2-oxo-2H-chromenylpyrazolecarboxylates
Kumar, J. Ashok,Saidachary,Mallesham,Sridhar,Jain, Nishant,Kalivendi, Shashi Vardhan,Rao, V. Jayathirtha,Raju, B. China
, p. 389 - 402 (2013/10/01)
2-Oxo-2H-chromenylpyrazolecarboxylates (8a-h and 12a-zb) have been synthesized by [3 + 2] cycloaddition of 2H-chromenophenylhydrazones (7a-h and 11a-w) with diethyl/dimethylbut-2-ynedioates. Phenylchromeno[4,3-c]pyrazol-4(1H) -ones (13i-n) were prepared from corresponding phenylhydrazones (7a-h) with catalytic amount of piperidine in presence of pyridine as a solvent at 100°C. All the synthesized compounds (8a-h, 12a-zb and 13a-n) were screened for anticancer activity against three human cancer cell lines such as prostate (DU-145), lung adenocarcinoma (A549), and cervical (HeLa) by standard MTT assay method. Further, photophysical properties (UV and fluorescence) for these compounds were discussed.
Synthesis and antimicrobial screening of 4H-2-acetyl-3-acetyamido furo[3,2-c] benzopyran 4-one, 11H-2,4-dimethyl-3,4-dihydro-3-amino-4-hydroxy- pyrimido [3,2-d]furo [3,2-c] benzopyran-11-one and 4H-2-acetyl-3-(3′- methyl-1′,2′,4′-triazol-4′-yl) furo[3,2-c] benzopyran 4-one
Mulwad,Hegde
scheme or table, p. 1558 - 1564 (2010/03/24)
A suspension of 4H-2-acctyl-3-amino furo [3,2-c] benzopyran 4-onc 5a-d in aqueous sodium hydroxide is treated with acetyl chloride to give 4H-2-acelyl-3-acclylamido furo[3,2-c] benzopyran 4-onc 6a-d. The compounds 6a-d and hydrazine hydrate in absolute alcohol is relluxed to give 11H-2,4-dimethyl-3,4-dihydro-3-amino-4-hydroxy-pyrimido[3,2-d] furo [3,2c]benzopyran-11-one 7a-d which in formic acid is relluxed for 5 hr to give 4H-2-acetyl-3-(3′-methyl-1′,2′,4′-triazol-4′-yl) furo[3.2-c]benzopyran 4-one 8a-d. The structures of all these compounds have been established on the basis of the spectral and analytical data. All compounds have showed good antimicrobial activity.
