51070-06-5

Upstream product

• 13252-83-0 4-hydroxy-6-methylcoumarin 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 140-39-6 1-acetoxy-4-methylbenzene 
• 106-44-5 p-cresol 
• 1448308-13-1 C₁₇H₁₃ClN₂O₂ 
• 51069-84-2 4-chloro-6-methyl-2-oxo-2H-chromene-3-carbaldehyde 
• 126214-23-1 4-hydroxy-6-methyl-2-oxo-2H-1-benzopyran-3-carboxaldehyde 
• 100-63-0 phenylhydrazine 
• 51069-97-7 4-chloro-6-methyl-2-oxo-2H-chromene-3-carbaldehyde phenylhydrazone 

Relevant academic research and scientific papers

Synthesis, anticancer activity and photophysical properties of novel substituted 2-oxo-2H-chromenylpyrazolecarboxylates

2-Oxo-2H-chromenylpyrazolecarboxylates (8a-h and 12a-zb) have been synthesized by [3 + 2] cycloaddition of 2H-chromenophenylhydrazones (7a-h and 11a-w) with diethyl/dimethylbut-2-ynedioates. Phenylchromeno[4,3-c]pyrazol-4(1H) -ones (13i-n) were prepared from corresponding phenylhydrazones (7a-h) with catalytic amount of piperidine in presence of pyridine as a solvent at 100°C. All the synthesized compounds (8a-h, 12a-zb and 13a-n) were screened for anticancer activity against three human cancer cell lines such as prostate (DU-145), lung adenocarcinoma (A549), and cervical (HeLa) by standard MTT assay method. Further, photophysical properties (UV and fluorescence) for these compounds were discussed.

Synthesis of some of the antibacterial compounds from 4-hydroxycoumarins: Part II

4-Hydroxy-2H-2-oxo-3-methylidene-urea[1]benzopyrans 2a-d, 4-hydroxy-2H-2-oxo-3-methylidene-thiourea[1]benzopyrans 2e-h, 4-hydroxy-2H-2-oxo-3-methylidene-guanidine[1]benzopyrans 2i-I are obtained from 1a-d on treatment with urea, thiourea, and guanidine re