510748-36-4

Basic information

• Product Name: tert-butyl 2-hydroxy-7-azabicyclo[2.2.1]heptane-7-carboxylate
• CAS NO: 510748-36-4
• Molecular Weight: 213.277
• Mol File: 510748-36-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-hydroxy-7-azabicyclo[2.2.1]heptane-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-hydroxy-7-azabicyclo[2.2.1]heptane-7-carboxylate(510748-36-4)
• EPA Substance Registry System: tert-butyl 2-hydroxy-7-azabicyclo[2.2.1]heptane-7-carboxylate(510748-36-4)

Safety Data

• Hazardous Substances Data: 510748-36-4(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 191468-74-3 7-azabicyclo[2.2.1]heptan-2-ol 
• 192118-47-1 tert-butyl 7-azabicyclo[2.2.1]hept-2-ene-7-carboxylate 
• 152533-47-6 (exo)-7-(1,1-dimethylethoxycarbonyl)-7-azabicyclo[2.2.1]heptan-2-one 

Downstream Products

• 163513-98-2 2-oxo-7-azabicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester 
• 1319725-09-1 (1S,4'R,5'R)-tert-butyl 4',5'-diphenyl-7-azaspiro[bicyclo[2.2.1]heptane-2,2'-imidazolidine]-7-carboxylate 
• 1318114-94-1 (1R,4'R,5'R)-tert-butyl 4',5'-diphenyl-7-azaspiro[bicyclo[2.2.1]heptane-2,2'-imidazolidine]-7-carboxylate 
• 163513-99-3 (1S,4R)-7-(tert-Butoxycarbonyl)-7-azabicyclo<2.2.1>heptan-2-one 
• 152533-46-5 7-<(1,1-dimethylethoxy)carbonyl>-7-azabicyclo<2.2.1>heptan-2-endo-ol 
• 154905-38-1 (+)-exo-7-<(1,1-Domethylethoxy)carbonyl>-7-azabicyclo<2.2.1>heptan-2-ol 
• 152533-47-6 (exo)-7-(1,1-dimethylethoxycarbonyl)-7-azabicyclo[2.2.1]heptan-2-one 

Relevant articles and documents

Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues

Conformationally constrained epibatidine analogues 20a,b and 23a,b were synthesized using a radical cyclization as the key step. Radioligand displacement assays to six defined rat nicotinic acetylcholine receptor (nAChR) subtypes showed that 20a,b bind with moderate affinities, while 23a,b have low affinities. 20a exhibits higher affinity for the β2 containing subtype than for the β4 containing counterpart, while 20b possesses reversed selectivity. Modeling studies suggest that the spatial distribution of the ligand's atoms around the pharmacophore elements may control their nAChR subtype selectivity.

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