51089-06-6

Basic information

• Product Name: 2-oxo-N-phenylcyclohexanecarboxaMide
• Synonyms: 2-oxo-N-phenylcyclohexanecarboxaMide
• CAS NO: 51089-06-6
• Molecular Formula: C₁₃H₁₅NO₂
• Molecular Weight: 217.2637
• Mol File: 51089-06-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-oxo-N-phenylcyclohexanecarboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxo-N-phenylcyclohexanecarboxaMide(51089-06-6)
• EPA Substance Registry System: 2-oxo-N-phenylcyclohexanecarboxaMide(51089-06-6)

Safety Data

• Hazardous Substances Data: 51089-06-6(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 41302-34-5 2-(methoxycarbonyl)cyclohexanone 
• 62-53-3 aniline 
• 28637-56-1 2,2-dimethyl-5,6,7,8-tetrahydro-4H-benzo[d][1,3]dioxin-4-one 
• 132723-22-9 2-Oxocyclohexylidenemethanone 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 

Downstream Products

• 127603-96-7 Methanesulfonic acid (1R,2S)-2-phenylcarbamoyl-cyclohexyl ester 
• 127603-96-7 Methanesulfonic acid (1S,2S)-2-phenylcarbamoyl-cyclohexyl ester 
• 127604-08-4 (1S,2R)-2-Bromo-cyclohexanecarboxylic acid phenylamide 
• 127604-03-9 (1S,6R)-7-Phenyl-7-aza-bicyclo[4.2.0]octan-8-one 
• 32119-42-9 N-phenylcyclohex-1-enecarboxamide 
• 28870-35-1 3-amino-1-oxo-2-phenyl-1,2,5,6,7,8-hexahydroisoquinoline-4-carbonitrile 
• 855428-14-7 2-Hydroxy-cyclohexanecarboxylic acid phenylamide 
• 59846-79-6 2-Aminocyclohexen-1-carboxanilid 

Relevant articles and documents

Highly Selective Difluoromethylations of β-Keto Amides with -TMSCF 2Br under Mild Conditions

Without employing any transition metal and other additives, efficient methods for selective difluoromethylations of β-keto amides with TMSCF 2 Br reagent have been developed under mild conditions. This protocol allows a convenient access to various α-difluoromethyl β-keto amides with excellent yields (up to 93%) and high carbon/oxygen (C/O) regioselectivities (up to 99:1). The C/O selectivity of β-keto amides could be easily reversed and controlled by simply changing the base. This protocol can be easily scaled-up and the C-difluoromethylation product could be reduced into CF 2 H-containing amino alcohol derivatives. Moreover, the first enantioselective electrophilic difluoromethylation of β-keto amides has been achieved by phase-transfer catalysis.

A Chiral Phenanthroline Ligand with a Hydrogen-Bonding Site: Application to the Enantioselective Amination of Methylene Groups

A silver-catalyzed amination is reported that occurs at the aliphatic C3-substituent of various quinolones and pyridones. The C-H amination reaction proceeded with high site-and enantioselectivity (14 examples, 83-97% ee). The key to its success is the use of a chiral phenanthroline ligand that is attached via an ethynyl linker to the 8-position of octahydro-1H-4,7-methanoisoindol-1-one. AgPF6 (10 mol %) served as the silver source, PhI.NNs as the nitrene precursor, and 1,10-phenanthroline as the coligand. The reaction outcome can be understood by assuming a nitrene C-H insertion within a hydrogen-bonded silver complex in which a single C-H bond is exposed to the catalytic reaction center.

4-Alkyl- and 3,4-dialkyl-1,2,3,4-tetrahydro-8-pyridono[5,6- g]quinolines: Potent, nonsteroidal androgen receptor agonists

A series of human androgen receptor (hAR) agonists based on 4-alkyl-; 4,4-dialkyl-; and 3,4-dialkyl-1,2,3,4-tetrahydro-8-pyridono[5,6-g]quinoline was synthesized and evaluated in competitive receptor binding assays and an androgen receptor cotransfection assay in a mammalian cell background. A number of compounds in this series demonstrated activity equal to or better than dihydrotestosterone in both assays and represent a novel class of compounds for use in androgen replacement therapy.