51101-42-9

Upstream product

• 719-59-5 5-chloro-2-aminobenzophenone 
• 23864-26-8 6-chloro-2-oxo-4-phenyl-1,2-dihydro-quinoline-3-carbonitrile 
• 123-75-1 pyrrolidine 
• 51101-11-2 2,6-dichloro-4-phenyl-quinoline-3-carbonitrile 

Downstream Products

• 1433901-74-6 6-chloro-4-phenyl-2-pyrrolidin-1-yl-3-(1H-tetrazol-5-yl)-quinoline 

Relevant academic research and scientific papers

NEW ARYL-QUINOLINE DERIVATIVES

The invention provides novel compounds having the general formula (I), wherein R1, R2, R3, R4 R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds.

ARYL-QUINOLINE DERIVATIVES

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds. The present compounds are useful as fatty-acid binding protein (FABP) 4 and/or 5 inhibitors and may be used for the treatment or prophylaxis of lipodystrophy, type 2 diabetes, dyslipidemia, atherosclerosis, liver diseases involving inflammation, steatosis and/or fibrosis, such as non-alcoholic fatty liver disease, in particular non-alcoholic steatohepatitis, metabolic syndrome, obesity, chronic inflammatory and autoimmune inflammatory diseases.