51116-29-1

Usage

Uses

Used in Pharmaceutical Industry:
2,3-dimethoxybenzo[c][1,3]dioxolo[4,5-j]phenanthridine is used as a lead compound for drug discovery and development due to its potential pharmacological properties, such as antimicrobial, antifungal, and antitumor activities. Its interactions with biological targets make it a valuable candidate for the creation of new therapeutic agents.
Used in Medicinal Chemistry Research:
2,3-dimethoxybenzo[c][1,3]dioxolo[4,5-j]phenanthridine is used as a subject of study in medicinal chemistry to explore its unique structure and potential biological activities. This research aims to understand its interactions with biological targets and its potential applications in the development of new drugs and therapies.
Used in Pharmacology Research:
2,3-dimethoxybenzo[c][1,3]dioxolo[4,5-j]phenanthridine is used as a research subject in pharmacology to investigate its potential pharmacological properties and interactions with biological targets. This research can contribute to the development of new therapeutic strategies and the improvement of existing treatments.

Upstream product

• 51116-28-0 2,3-dimethoxy-4b,11b,12,13-tetrahydro-benzo[c][1,3]dioxolo[4,5-j]phenanthridine 
• 98799-57-6 2,3-Dimethoxy-12,13-dihydro-8,10-dioxa-5-aza-cyclopenta[b]chrysene 
• 180411-20-5 N-(2-Benzo[1,3]dioxol-5-yl-6,7-dimethoxy-naphthalen-1-yl)-formamide 
• 94838-88-7 2-formyl-4,5-(methylenedioxy)benzeneboronic acid 
• 180411-16-9 2-bromo-6,7-dimethoxy-1-naphthylamine 
• 13575-75-2 6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydronaphthalene 
• 180411-10-3 2-bromo-6,7-dimethoxy-1-naphthol 
• 180411-08-9 2,2-Dibromo-6,7-dimethoxy-3,4-dihydro-2H-naphthalen-1-one 
• 180411-18-1 N-(2-Bromo-6,7-dimethoxy-naphthalen-1-yl)-formamide 
• 213698-50-1 N-(2-bromo-6,7-dimethoxy-1-naphthyl)-2-hydroxy-2-methylpropanamide 
• 180411-12-5 2-(2-bromo-6,7-dimethoxy-1-naphthyloxy)-2-methylpropanamide 
• 13575-74-1 4-(3,4-dimethoxyphenyl)butanoic acid 
• 2620-50-0 1,3-benzodioxol-5-ylmethyl amine 
• 59682-83-6 N-(2H-benzo[3,4-d]-1,3-dioxolen-5-ylmethyl)acetamide 

Downstream Products

• 51116-34-8 2,3,6-trimethoxy-5-methyl-5,6-dihydro-benzo[c][1,3]dioxolo[4,5-j]phenanthridine 

Relevant academic research and scientific papers

Rapid and convergent assembly of natural benzo[c]phenanthridines by palladium/norbornene catalysis

A straightforward total synthesis of a small panel of natural benzo[c]phenanthridines is described. The selective coupling of an aryl triflate with a bromobenzylamine by means of palladium/norbornene joint catalysis and a sequential transfer hydrogenation

A versatile synthesis of fully aromatic benzo[c]phenanthridine alkaloids

A versatile new approach for the synthesis of benzo[c]phenanthridine alkaloids is described and is illustrated by the preparation of eight different alkaloids. The key steps are Smiles rearrangements, which allow easy access to 2-bromo-1-naphthylamines from 2-bromo-1-naphthols, and the attachment of the D-ring unit by Suzuki coupling.

A versatile synthesis of benzo[c]phenanthridine alkaloids

Suzuki coupling between 2-bromo-1-formamidonaphthalenes and arylboronic acids is the key step in a versatile synthesis of benzo[c]phenanthridine alkaloids, illustrated by the synthesis of norallonitidine, nornitidine, noravicine, allonitidine, nitidine and avicine.

Direct Synthesis of Benzophenanthridines and Benzophenanthridones via SRN1 Reactions

A straightforward and high-yield route to the 11,12-dihydrobenzophenanthridine (3) and 11,12-dihydrobenzophenanthridone (14) ring systems is based upon an SRN1 reaction between 2-halobenzylamines 1 or 2-halobenzoic acids 11 and enolates derived from tetralones 2.The efficient dehydrogenation of 3 or 14 gives the benzophenthridines 4 or benzophenanthridones 15.Use of properly substituted reactants leads to nitidine, avicine, and fagaronine and to analogues of those natural products.