51118-27-5

Basic information

• Product Name: 1H-1,2,3-Triazole, 5-phenyl-1-(phenylmethyl)-
• CAS NO: 51118-27-5
• Molecular Formula: C15H13N3
• Molecular Weight: 235.288
• Mol File: 51118-27-5.mol
• Article Data: 72

Chemical Properties

• CAS DataBase Reference: 1H-1,2,3-Triazole, 5-phenyl-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,3-Triazole, 5-phenyl-1-(phenylmethyl)-(51118-27-5)
• EPA Substance Registry System: 1H-1,2,3-Triazole, 5-phenyl-1-(phenylmethyl)-(51118-27-5)

Safety Data

• Hazardous Substances Data: 51118-27-5(Hazardous Substances Data)

Usage

Chemical structure

A triazole derivative with a phenylmethyl group and a phenyl group attached to the 5-position of the triazole ring

Potential applications

Building block for the synthesis of pharmaceuticals, agrochemicals, and materials, development of coordination polymers and metal-organic frameworks

Importance

Valuable intermediate in organic synthesis, promising candidate for further research in drug discovery and material science.

Upstream product

• 536-74-3 phenylacetylene 
• 622-79-7 benzyl azide 
• 637-44-5 phenylpropyolic acid 
• 100-39-0 benzyl bromide 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 108-86-1 bromobenzene 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 100-44-7 benzyl chloride 
• 1422251-36-2 3-benzyl-1-(3,4-dimethoxybenzyl)-4-phenyl-1H-1,2,3-triazolium bromide 
• 20964-95-8 (2Z)-3-(benzylamino)-1,3-diphenyl-prop-2-en-1-one 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 100-46-9 benzylamine 
• 1854-83-7 α-(4-Chlor-benzol-sulfonyl)-styrol 
• 100-52-7 benzaldehyde 

Downstream Products

• 1111662-64-6 ethyl 4-(1-benzyl-5-phenyl-1H-1,2,3-triazol-4-yl)benzoate 
• 111091-83-9 1-ethyl-3-benzyl-4-phenyl-[1,2,3]triazolium; iodide 
• 108878-81-5 1,3-diethyl-4-phenyl-1,2,3-triazolium iodide 

Relevant articles and documents

Preparation of ruthenium azido complex containing a Tp ligand and ruthenium-catalyzed cycloaddition of organic azides with alkynes in organic and aqueous media: Experimental and computational studies

The catalytic activity of a series of ruthenium azido complexes containing Tp ligands has been evaluated for the cycloaddition of terminal alkynes and azides to give selectively 1,5-disubstituted 1,2,3-triazoles. The complex Tp(PPh3)(EtNH2)RuN3 (2, Tp = HB(pz)3, pz = pyrazolyl) was found to be an effective catalyst for the cycloaddition reactions. In the presence of complex 2, azides reacted with a range of terminal alkynes containing various functionalities to selectively produce 1,5-disubstituted 1,2,3-triazoles. Theoretical calculations support the proposed mechanism.

Multi-component reaction for the preparation of 1,5-disubstituted 1,2,3-triazoles by in-situ generation of azides and nickel-catalyzed azide-alkyne cycloaddition

An efficient one-pot procedure combining bromide conversion into azide followed by NiAAC for the preparation of 1,5-disubstituted 1,2,3-triazoles has been developed. This procedure prevents the use of isolated azides, which are insufficiently commercially

Ag-NHC anchored on silica: An efficient ultra-low loading catalyst for regioselective 1,2,3-triazole synthesis

A silica-supported silver complex, Ag-NHC@SiO2, was prepared by an anchoring coordination technique, which was successfully employed for the click reaction under mild reaction conditions. The protocol offered the remarkable advantages of operat