511274-73-0Relevant articles and documents
A convergent ring-closing metathesis approach to carbohydrate-based macrolides with potential antibiotic activity
Blom, Petra,Ruttens, Bart,Van Hoof, Steven,Hubrecht, Idzi,Van Der Eycken, Johan,Sas, Benedikt,Van Hemel, Johan,Vandenkerckhove, Jan
, p. 10109 - 10112 (2007/10/03)
An efficient convergent approach has been developed for the construction of novel, non-natural, carbohydrate-based macrolides. The key step in the synthesis is the formation of the macrocyclic ring via a ring-closing metathesis reaction. The obtained macrolide analogues have been screened for biological activity against Gram-positive and Gram-negative bacteria, including resistant strains, yeasts, and molds.