51135-39-8

Usage

Uses

Used in Pharmaceutical Industry:
5-Benzyloxindole is used as a key intermediate in the synthesis of various pharmaceuticals and biologically active compounds. Its unique structure and properties make it a promising candidate for the development of new drugs with potential therapeutic applications.
Used in Cancer Treatment Research:
In the field of cancer treatment, 5-Benzyloxindole is used as a research compound to explore its potential as an anticancer agent. Its ability to interact with specific biological targets and modulate signaling pathways may contribute to the inhibition of tumor growth and progression.
Used in Neurological Disorders Research:
5-Benzyloxindole is also utilized in the study of neurological disorders, where it may have potential applications in the development of treatments for conditions such as Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders. Its interaction with specific receptors and enzymes involved in these diseases could provide new avenues for therapeutic intervention.
Used in Organic Synthesis:
As a building block in organic synthesis, 5-Benzyloxindole is used to create other important molecules with various applications. Its versatility allows for the development of new compounds with potential uses in different industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 59-48-3 2-oxoindole 
• 98-88-4 benzoyl chloride 
• 1137-41-3 (4-aminophenyl)(phenyl)methanone 

Downstream Products

• 51579-81-8 2-amino-5 benzoyl-phenylacetic acid 

Relevant academic research and scientific papers

Umbelliferone-oxindole hybrids as novel apoptosis inducing agents

In furtherance of our endeavour towards the synthesis of novel bioactive agents, a panel of (E)-3-((7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methylene)indolin-2-one derivatives were synthesized using diverse 5-substituted oxindoles and 7-hydroxy-4-methyl-

Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors

The present invention relates to inhibitors of protein kinases of formula I: which can be used in the treatment of various diseases, notably cancer, inflammation or disorders of the central nervous system. It also relates to pharmaceutical compositions containing the compounds according to the invention and their use in therapy.

Cycloalkyl - containing 5-acylindolinones, the preparation thereof and their use as medicaments

The present invention relates to cycloalkyl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined as in claims 1 to 6, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).

NOVEL ARYL-CONTAINING 5-ACYLINDOLINONES, THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS

The invention relates to aryl-containing 5-acylindolinones of general formula (I) in which R1 to R3 are defined as in Claims 1 to 7, the tautomers, enantiomers, diastereomers, mixtures and salts thereof, all of which having valuable

Alkyl-containing 5-acylindolinones, the preparation thereof and their use as medicaments

The present invention relates to alkyl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have val

NOVEL ALKYL-CONTAINING 5-ACYLINDOLINONES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL PRODUCTS

The invention relates to alkyl-containing 5-acylindolinones of the general formula (I), where R1 to R3 are as defined in claim 1, and to tautomers, enantiomers, diastereomers, mixtures and salts thereof with valuable pharmacological

NOVEL CYCLOALKYL-CONTAINING 5-ACYLINDOLINONES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL PRODUCTS

The invention relates to cycloalkyl-containing 5-acylindolinones of the general formula (I), where R1 to R3 are as defined in claims 1 to 6, and to tautomers, enantiomers, diastereomers, mixtures and salts thereof with valuable pharmacological properties, more particularly an inhibitory effect on protein kinases, more particularly an inhibitory effect on the activity of glycogen synthase kinase (GSK-3).

Aryl-containing 5-acylindolinones, the preparation thereof and their use as medicaments

The present invention relates to aryl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valu

Unsymmetrical Diarylketones from Electron-rich Heterocyclic Arenes

AlCl3-mediated chlorocarbonylation of a first arene by oxalyl chloride followed by in situ Friedel-Crafts acylation of a second electron-rich arene expeditiously provides, in a one-pot procedure, either symmetrical or unsymmetrical benzophenones with yields ranging from 17-52%. Best results are obtained when the more activated substrate is used as the second arene. Another advantage is that the resultant benzophenone precipitates from the reaction mixture allowing facile workup.

The discovery of potent cRaf1 kinase inhibitors

A series of benzylidene-1H-indol-2-one (oxindole) derivatives was synthesized and evaluated as cRaf-1 kinase inhibitors. The key features of the molecules were the donor/acceptor motif common to kinase inhibitors and a critical acidic phenol flanked by two substitutions. Diverse 5-position substitutions provided compounds with low nanomolar kinase enzyme inhibition and inhibited the intracellular MAPK pathway. (C) 2000 Elsevier Science Ltd. All rights reserved.