51138-52-4

Upstream product

• 5751-48-4 2-methylchromone 

Downstream Products

• 51138-54-6 2-styryl-4-thiochromone 
• 51138-45-5 1-phenyl-3-methyl-5-(2'-hydroxyphenyl)pyrazole 
• 51138-46-6 3⁽⁵⁾-methyl-5⁽³⁾-(2-hydroxyphenyl)pyrazole 
• 88912-80-5 4-Diphenylmethylene-2-methyl-4H-1-benzopyran 
• 15058-15-8 2-(2-methyl-4H-1-benzopyran-4-ylidene)propanedinitrile 
• 5751-48-4 2-methylchromone 
• 120869-49-0 2-(3-Methyl-isothiazol-5-yl)-phenol 
• 51138-49-9 5-(2-hydroxyphenyl)-3-methylisoxazole 

Relevant academic research and scientific papers

α1-Adrenoceptor agonists: The identification of novel α1A subtype selective 2′-heteroaryl-2-(phenoxymethyl)imidazolines

Novel 2′-heteroaryl-2-(phenoxymethyl)imidazolines have been identified as potent agonists of the cloned human α1-adrenoceptors in vitro. The nature of the 2′-heteroaryl group can have significant effects on the potency, efficacy, and subtype selectivity in this series. α1A Subtype selective agonists have been identified.

Selenium Dioxide Oxidation of Alkylcoumarins and Related Methyl-Substituted Heteroaromatics

By the use of selenium dioxide as the specific oxidizing agent in the coumarin series, the 4-ethyl, 4-propyl and 4-benzyl substituents of coumarin were converted into α-alcohols 2 and/or ketones 3, while 3-methyl- and 3-benzylcoumarins were converted into 3-acyl derivatives 7.The methyl substituent of the analogous thiocoumarin 5, chromones 10 or thiochromone 11 was also oxidized into the formyl functionality.Facile oxidative desulfurization into the ketone functionality, prior to methyl oxidation, was observed for the thione derivatives of 1a, 5, 6 and 10.