51138-45-5

Usage

Uses

Used in Pharmaceutical Industry:
Phenol, 2-(3-methyl-1-phenyl-1H-pyrazol-5-yl)is used as a chemical intermediate for the synthesis of pharmaceutical drugs. Its unique structure allows for the creation of new drugs with diverse biological activities, contributing to the development of novel therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, Phenol, 2-(3-methyl-1-phenyl-1H-pyrazol-5-yl)is utilized as a precursor in the production of agrochemicals. Its properties make it a valuable component in the synthesis of compounds that can be used in agricultural applications, such as pesticides or herbicides, to improve crop protection and yield.

Upstream product

• 5751-48-4 2-methylchromone 
• 100-63-0 phenylhydrazine 
• 51138-52-4 2-methylbenzopyran-4-thione 
• 16636-62-7 1-(2'-hydroxyphenyl)butane-1,3-dione 
• 64-17-5 ethanol 
• 51751-37-2 2-Methyl-4-oxo-4H-<1>benzopyran-3-carboxylic acid 
• 59-88-1 phenylhydrazine hydrochloride 
• 931-55-5 phenyl-diazene 
• 67140-88-9 2-Methyl-4-oxo-4H-<1>benzopyran-3-carbonitrile 
• 10037-20-4 3-acetyl-2-methyl-4-oxo-4H-<1>benzopyran 

Relevant academic research and scientific papers

Reaction of aryl and heterocyclyhydrazines with 2-methylchromone: Structural investigation of the products

Reaction of 2-methylchromone (2) with phenylhydrazine provides 3-methyl-5-(o-hydroxyphenyl)-1-phenylpyrazole (6) as a major product. In contrast under similar conditions, heterocyclyhydrazines (8a-c) yield exclusively 5-ethyl-3-(o-hydroxyphenyl)-1-heterocyclylpyrazoles (9a-c). The structural assignments are based on an unambiguous synthesis and an analysis of NMR (1H and 13C) spectral data.

Benzopyrans: Part XX - 4-Oxo-4H-benzopyran-3-carbonitrile/Carboxylic Acid: Change of Their Reaction Courses by a Methyl Substituent at 2-Position

2-Methyl-4-oxo-4H-benzopyran-3-carbonitriles (1b) and the corresponding carboxylic acids (2b), unlike their 2-unsubstituted analogues (1a) and (2a), give with phenyl hydrazine the hydrazones (6b) and the pyrazoles (13b), respectively.The hydrazones (6b) have been converted into the benzopyranopyrazoles (8b).

INVESTIGATIONS IN THE CHROMONE SERIES. PART XI. REACTIONS OF METHYLCHROMONES AND METHYL-4-THIOCHROMONES WITH PHENYLHYDRAZINE

Reactions of 6-methyl-, 2-methyl- and 2,8-dimethylchromones, as well as of 6-methyl-, 8-methyl- and 2,8-dimethyl-4-thiochromones with phenylhydrazine have been investigated.A lack of reactivity in thiocarbonyl group in 4-thiochromone system has been established.Intermediate products of reactions have been separated, their structure established and the reaction course described.

Synthesis of Some Imidazole- and Pyrazole- Derived Chelating Agents

Procedures involving condensation of o-phenylenediamines with carboxylic acids, and reaction of bifunctional alkyl halides with bifunctional nucleophiles are described.Syntheses are reported of 2,6-bis(2-benzimidazyl)-pyridine, 1,3-bis(2-benzimidazyl)-2-thiapropane, 1,7-bis(2-benzimidazyl)-2,6-dithiaheptane, 2-hydroxymethyl-5,6-dimethylbenzimidazole, 2-chloromethyl-5,6-dimethylbenzimidazole hydrochloride, 1,7-bis(5,6-dimethyl-2-benzimidazyl)-2,6-dithiaheptane, 3,6-bis(1-pyrazolyl)pyridazine, 2-(2-hydroxy-3-methylphenyl)benzimidazole, 2-(2-hydroxyphenyl)benzimidazole, 5-(2-hydroxyphenyl)-3-methyl-1-phenylpyrazole, 3(5)-(2-hydroxyphenyl)-5(3)-methylpyrazole, 3(5)-(2-hydroxyphenyl)-5(3)-phenylpyrazole, and 1,3-bis((5-methylpyridyl)imino)isoindoline.