18085-97-7

Basic information

• Product Name: 5,7-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6-methoxy-chromen-4-one
• Synonyms: 5,7-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6-methoxy-chromen-4-one;3',6-Dimethoxy-4',5,7-trihydroxyflavone;5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one;6-Hydroxyluteolin 3',6-dimethyl ether;Jacesiolin;4',5,7-Trihydroxy-3',6-dimethoxyflavone;4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-;5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-chromen-4-one
• CAS NO: 18085-97-7
• Molecular Formula: C₁₇H₁₄O₇
• Molecular Weight: 330.29
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 18085-97-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 259-260 °C
• Boiling Point: 619 °C at 760 mmHg
• Flash Point: 232 °C
• Appearance: /
• Density: 1.483 g/cm³
• Vapor Pressure: 6.48E-16mmHg at 25°C
• Refractive Index: 1.67
• Storage Temp.: 2-8°C(protect from light)
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated), Pyridine (Slightly)
• PKA: 6.47±0.40(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 5,7-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6-methoxy-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6-methoxy-chromen-4-one(18085-97-7)
• EPA Substance Registry System: 5,7-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6-methoxy-chromen-4-one(18085-97-7)

Safety Data

• Hazardous Substances Data: 18085-97-7(Hazardous Substances Data)

Usage

Uses

Jaceosidin exhibits anti-allergic, anti-inflammatory and apoptosis inducing activities.

Definition

ChEBI: A trihydroxyflavone that is flavone with hydroxy groups at positions 5, 7 and 4' and methoxy groups at positions 3' and 6. Isolated from Salvia tomentosa and Artemisia asiatica, it exhibits anti-allergic, anti-inflammatory and apo tosis inducing activties.

InChI:InChI=1/C17H14O7/c1-22-13-5-8(3-4-9(13)18)12-6-10(19)15-14(24-12)7-11(20)17(23-2)16(15)21/h3-7,18,20-21H,1-2H3

Upstream product

• 870480-47-0 2,6-diacetyl-3,4,5-trimethoxyphenol 
• 5533-00-6 3-methoxy-4-methoxymethoxy-benzaldehyde 
• 121-33-5 vanillin 
• 137527-38-9 2-(4-Hydroxy-3-methoxy-cinnamoyl)-3.4.5-trimethoxy-phenol 
• 22248-14-2 6-hydroxy-2,3,4-trimethoxyacetophenone 
• 51145-80-3 4'-hydroxy-5,6,7,3'-tetramethoxyflavone 

Downstream Products

• 18003-33-3 3',4',5,6,7-pentahydroxyflavone 
• 2306-27-6 sinensetin 
• 18085-98-8 5,7,4′-triacetoxyjaceosidin 
• 16981-97-8 arglanin 

Relevant articles and documents

Investigations on the glycoside from Centaurea jacea L. 3. Isolation, structure and synthesis of 4,5,7-trihydroxy-3,6-dimethoxy-flavon-7-mono-beta-D-glucopyranoside, a new flavone glycoside from the roots of Centaurea jacea L

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5, 7-dihydroxy-6-production of polymethoxyflavones

PROBLEM TO BE SOLVED: To provide an efficient production method of 5,7-dihydroxy-6-methoxyflavones in a short step. SOLUTION: The production method of 5,7-dihydroxy-6-methoxyflavones includes a step of demethylating 5,6,7-trimethoxy-8-acylflavones expressed by general formula (II). In the formula, n represents an integer of 0 to 5; R2represents a hydroxyl group or the like and when n is 2 or more, a plurality of R2may be the same or different from each other; and R3represents a 1-4C straight-chain or branched alkyl group or the like. COPYRIGHT: (C)2012,JPOandINPIT