10350-10-4Relevant articles and documents
Process method for producing 3-ethyl formate-4-hydroxy-2-pyridone by utilizing carbon dioxide
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Paragraph 0018; 0022; 0043-0044; 0053-0054, (2019/08/01)
The invention discloses a process method for producing 3-ethyl formate-4-hydroxy-2-pyridone by utilizing carbon dioxide. The process method comprises the following steps: weighing a 4-hydroxy-6-alkyl-2-pyridone substrate, a catalyst and potassium tert-butoxide to be added into a Schleck bottle, degassing, and continuously introducing 1atm of carbon dioxide; adding a solvent, and reacting in an oilbath; performing after-treatment after the reaction is completed so as to obtain a 3-carboxyl-4-hydroxy-2-pyridone compound 2; carrying out an esterification reaction among the obtained compound 2,(1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride), 2-methylaminopyridine and ethanol; performing column chromatography isolation after the reaction is completed, thereby obtaining the 3-ethyl formate-4-hydroxy-2-pyridone 3. According to the process method disclosed by the invention, the used catalyst is wide in source and low in price; the preparation process is simple, the equipment requirement is low, the raw material is wide in source and low in cost, the toxicity is low, and industrial scale-up production is easily realized.
Thermal Cyclization of 3-Acyl-4-azidopyridines to Isoxazolo[4,3-c]pyridines
Stadlbauer, Wolfgang,Fiala, Werner,Fischer, Michaela,Hojas, Gerhard
, p. 33 - 39 (2007/10/03)
4-Azidopyridines such as 3-acetyl-4-azido-2-pyridones 3 or 4-azido-3-ethoxycarbonylpyridine 7 with reactive ortho-acyl substituents were obtained from the 4-hydroxy-2-pyridones 1, resp. 5 via 4-tosyloxy-2-pyridones 2 or the 2,4-dichloropyridine 6. DSC-ass