51161-83-2

Upstream product

• 100-61-8 N-methylaniline 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 4282-82-0 N-methyl-N-propargylaniline 
• 51-80-9 bis-(dimethylamino)methane 

Relevant academic research and scientific papers

Oxidant-dependent Cu-catalyzed alkynylation and aminomethylation: C-H versus C-C cleavage in TMEDA

Oxidant-dependent Cu-catalyzed alkynylation and aminomethylation reactions have been achieved under facile and mild conditions. TMEDA coupled with various terminal alkynes via C-H bond cleavage in good yields using atmospheric oxygen as an oxidant. Switching from air to TBHP afforded aminomethylation products of terminal alkynes through C-C bond cleavage of TMEDA. The protocol provided a novel strategy to prepare bi/tridentate N-ligand.