4282-82-0

Basic information

• Product Name: N-Methyl-N-phenyl-2-propyne-1-amine
• Synonyms: (2-Propynyl)methylphenylamine;N-Methyl-N-(2-propynyl)aniline;N-Methyl-N-phenyl-2-propyne-1-amine;N-Methyl-N-propargylaniline;N-Phenyl-N-methyl-2-propyne-1-amine
• CAS NO: 4282-82-0
• Molecular Formula: C₁₀H₁₁N
• Molecular Weight: 145.2
• Mol File: 4282-82-0.mol
• Article Data: 27

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Methyl-N-phenyl-2-propyne-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-N-phenyl-2-propyne-1-amine(4282-82-0)
• EPA Substance Registry System: N-Methyl-N-phenyl-2-propyne-1-amine(4282-82-0)

Safety Data

• Hazardous Substances Data: 4282-82-0(Hazardous Substances Data)

Upstream product

• 100-61-8 N-methylaniline 
• 100-62-9 N-methylenebenzenamine 
• 14465-74-8 N-phenyl-N-prop-2-ynylamine 
• 77-78-1 dimethyl sulfate 
• 75-20-7 calcium carbide 
• 121-69-7 N,N-dimethyl-aniline 
• 124-38-9 carbon dioxide 
• 60256-44-2 N-Methyl-N-phenyl-2-bromo-2-propenylamine 
• 15497-51-5 N-((1H-benzo(d)(1,2,3)triazol-1-yl)methyl)-N-methylaniline 
• 624-65-7 2-propynyl chloride 
• 106-96-7 propargyl bromide 
• 62-53-3 aniline 
• 74-88-4 methyl iodide 

Downstream Products

• 51161-84-3 methyl-phenyl-(4-piperidin-1-yl-but-2-ynyl)-amine 
• 119403-35-9 methyl 4-(N-phenyl-N-methylamino)-2-butynoate 
• 1610597-57-3 4-(methyl(phenyl)amino)but-2-ynal 
• 1610597-71-1 (Z)-3-(dimethyl(phenyl)silyl)-4-(methyl(phenyl)amino)but-2-enal 
• 1616405-22-1 (E)-4-methyl-N-((1-methyl-1H-indol-3-yl)methylene)benzenesulfonamide 
• 19012-03-4 N-methyl-3-formylindole 
• 1329034-42-5 4-methyl-N-((1-methyl-1H-indol-3-yl)methyl)benzenesulfonamide 
• 1616405-21-0 N-methyl-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)benzenamine 
• 1616405-57-2 (E)-N-((1-methyl-1H-indol-3-yl)methylene)benzenesulfonamide 
• 1616405-49-2 N-methyl-N-((1-(phenylsulfonyl)-1H-1,2,3-triazol-4-yl)methyl)aniline 
• 100-61-8 N-methylaniline 
• 104967-55-7 2-[2-(3,4-dimethoxyphenyl)ethyl]-1-methyl-1,2,3,4-tetrahydroquinolineanol 

Relevant articles and documents

Copper(i)-catalysed intramolecular hydroarylation-redox cross-dehydrogenative coupling ofN-propargylanilines with phosphites

Intramolecular hydroarylation-redox cross-dehydrogenative coupling ofN-propargylanilines with phosphite diesters proceeded in the presence of Cu(i)-catalysts (20 mol%) to selectively give 2-phosphono-1,2,3,4-tetrahydroquinolines in good yields with 100% atomic utilization. P-H and two C-H bonds are activated at once and these hydrogen atoms are trapped by a propargylic triple bond in the molecule.

Pyridoxine-resveratrol hybrids as novel inhibitors of MAO-B with antioxidant and neuroprotective activities for the treatment of Parkinson's disease

A series of pyridoxine-resveratrol hybrids were designed and synthesized as monoamine oxidase B inhibitors for the treatment of Parkinson's disease. Most of them exhibited potent inhibitory activities on MAO-B with high selectivity. Specifically, compounds 12a, 12g and 12l showed the most excellent inhibition to hMAO-B with the IC50 values of 0.01 μM, 0.01 μM and 0.02 μM, respectively. Further reversibility study demonstrated that 12a and 12l were reversible and 12g was irreversible MAO-B inhibitors. Molecular docking studies of MAO revealed the binding mode and high selectivity of these compounds with MAO-B. In addition, these three representative compounds also exhibited low cytotoxicity and excellent neuroprotective effect in the test on H2O2-induced PC-12 cell injury. Moreover, 12a, 12g and 12l showed good antioxidant activities and high blood-brain barrier permeability. Overall, all of these results highlighted 12a, 12g and 12l were potential and excellent MAO-B inhibitors for PD treatment.

Ethyl lactate as a renewable carbonyl source for the synthesis of diynones

Ethyl lactate, a sustainable feedstock, serves as a highly attractive building block for the synthesis of value-added chemicals such as skipped diynones and, after gold-catalyzed transposition, conjugated diynones. Green solvents are involved in all steps