51183-49-4Relevant academic research and scientific papers
Regioselective Thiocarbonylation of Vinyl Arenes
Hirschbeck, Vera,Gehrtz, Paul H.,Fleischer, Ivana
, p. 16794 - 16799 (2016)
A palladium-catalyzed thiocarbonylation of styrene derivatives is reported for the first time. The combination of thiols as nucleophiles and a bidentate ligand ensures a unique reaction outcome with high regioselectivity toward the more valuable branched isomer and new reactivity. The ambient reaction conditions (temperature, catalyst loading) and the use of a CO surrogate render this transformation a useful method for the synthesis of thioesters from available feedstock. Various functional groups on arene and thiol substituents are tolerated by the system. Notably, challenging ortho-substituted styrenes are converted with unprecedentedly high regioselectivity.
