512176-91-9Relevant academic research and scientific papers
Catalysed asymmetric protonation of simple linear keto-enolic species a route to chiral α-arylpropionic acids
Roy, Olivier,Riahi, Abdelkhalek,Henin, Francoise,Muzart, Jacques
, p. 3986 - 3994 (2007/10/03)
The reaction cascade consisting of deprotection/decarboxylation/asymmetric protonation of enolic species, starting from open-chain benzyl β-oxo esters, has been studied. When carried out in the presence of catalytic amounts of cinchonine, the reaction gave optically active α-aryl ketones with up to 75% ee. Enantio-enriched (S)-3-phenyl-2-butanone can be converted into 2-phenylpropionic acid without racemisation. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
