512178-52-8Relevant academic research and scientific papers
Scalable solution-phase synthesis of the biologically active cyclodepsipeptide destruxin E, a potent negative regulator of osteoclast morphology
Yoshida, Masahito,Sato, Hiroshi,Ishida, Yoshitaka,Nakagawa, Hiroshi,Doi, Takayuki
, p. 296 - 306 (2014/01/17)
The scalable solution-phase synthesis of the cyclodepsipeptide destruxin E (1) has been achieved. Diastereoselective dihydroxylation of the terminal alkene in a 2-alkoxy-4-pentenoic amide, 7, was successfully accomplished utilizing (DHQD)2PHAL
A total synthesis of arenastatin A, an extremely potent cytotoxic depsipeptide, from the Okinawan marine sponge dysidea arenaria
Kobayashi,Kurosu,Wang,Kitagawa
, p. 2394 - 2396 (2007/10/02)
An asymmetric synthesis of a cyclic depsipeptide arenastatin A (1), which was isolated from the marine sponge Dysidea arenaria and exhibited extremely potent cytotoxicity with IC50 5 pg/ml for KB cells, has been accomplished.
