51226-14-3

Usage

Uses

Used in Organic Synthesis:
3-(2-METHYL-1,3-DIOXOLAN-2-YL)ANILINE is used as a synthetic intermediate for various organic synthesis processes. Its unique chemical properties, influenced by the dioxolane ring and the methyl group, make it a valuable component in the creation of more complex molecules.
Used in Pharmaceutical Industry:
3-(2-METHYL-1,3-DIOXOLAN-2-YL)ANILINE is used as a building block for the development of new pharmaceutical compounds. Its structural features allow for the creation of molecules with potential therapeutic applications, contributing to the advancement of drug discovery and design.
Used in Chemical Research:
3-(2-METHYL-1,3-DIOXOLAN-2-YL)ANILINE is used as a research tool in the field of chemistry. Its unique properties and reactivity make it an interesting subject for studying reaction mechanisms, exploring new synthetic routes, and understanding the relationship between molecular structure and chemical behavior.

InChI:InChI=1/C10H13NO2/c1-10(12-5-6-13-10)8-3-2-4-9(11)7-8/h2-4,7H,5-6,11H2,1H3

Upstream product

• 134812-02-5 2-methyl-2-(3-trifluoroacetylamino)phenyl-1,3-dioxolane 
• 1111249-40-1 4-methyl-N-(3-(2-methyl-1,3-dioxolan-2-yl)phenyl)benzenesulfonamide 
• 39172-32-2 2-(3-bromophenyl)-2-methyl-[1,3]dioxolane 
• 99-03-6 1-(3-aminophenyl)ethanone 
• 104-15-4 toluene-4-sulfonic acid 
• 56915-87-8 3-trifluoroacetamidoacetophenone 
• 121-89-1 3-Nitroacetophenone 
• 51226-13-2 2-methyl-2-(3-nitrophenyl)-[1,3]dioxolane 

Downstream Products

• 268234-36-2 dimethyl 4-({methoxycarbonyl-[3-(2-methyl-[1,3]dioxolan-2-yl)phenyl]amino}methyl)phthalate 
• 1111249-40-1 4-methyl-N-(3-(2-methyl-1,3-dioxolan-2-yl)phenyl)benzenesulfonamide 
• 134812-22-9 1-Ethyl-4-oxo-7-(2-phenyl-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid 
• 251955-48-3 2-[3-(2-methyl-[1,3]dioxolan-2-yl)-phenylamino]-3-nitro-benzoic acid 
• 134812-04-7 diethyl 3-(2-methyl-1,3-dioxolan-2-yl)anilinomethylenemalonate 
• 251955-49-4 2-(3-Acetylanilino)-3-nitrobenzoic acid 
• 237428-12-5 2-<3-(1-hydroxyethyl)anilino>-3-nitrobenzoic acid 

Relevant academic research and scientific papers

AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS

In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions.

Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds

Arylmetals are highly valuable carbon nucleophiles that are readily and inexpensively prepared from aryl halides or arenes and widely used on both laboratory and industrial scales to react directly with a wide range of electrophiles. Although C-C bond formation has been a staple of organic synthesis, the direct transfer of primary amino (-NH2) and hydroxyl (-OH) groups to arylmetals in a scalable and environmentally friendly fashion remains a formidable synthetic challenge because of the absence of suitable heteroatom-transfer reagents. Here, we demonstrate the use of bench-stable N-H and N-alkyl oxaziridines derived from readily available terpenoid scaffolds as efficient multifunctional reagents for the direct primary amination and hydroxylation of structurally diverse aryl- and heteroarylmetals. This practical and scalable method provides one-step synthetic access to primary anilines and phenols at low temperature and avoids the use of transition-metal catalysts, ligands and additives, nitrogen-protecting groups, excess reagents and harsh workup conditions.

Instantaneous deprotection of tosylamides and esters with Sml 2/amine/water

(Chemical Equation Presented) Sml2/amine/water mediates instantaneous cleavage of tosyl amides and tosyl esters. Highly hindered, sensitive and functionalized substrates were successfully deprotected in near quantitative yield.

Imidazole derivatives as histamine receptor H3 (ANT) agonists

Novel imidazole derivatives as histamine receptor H3antagonists and/or agonists, preparation thereof and therapeutical uses thereof. Chemical compounds for use as histamine receptor H3agonists, partial agonists or antagonists, having general formula (Ia) or (Ib), the use thereof for making drugs, and methods for revealing the agonist, partial agonist or antagonist activity of such compounds in vivo, are disclosed.

Phenazines and natural products; novel synthesis of saphenic acid

The natural product saphenic acid (6-(1-hydroxyethyl)1- phenazinecarboxylic acid) was synthesized from readily accessible starting materials. The desired product was obtained in an overall yield of 22% for four steps with the key steps being formation of