51226-13-2

Usage

Uses

Used in Pharmaceutical Research and Development:
2-Methyl-2-(3-nitrophenyl)-1,3-dioxolane is used as an intermediate in the synthesis of various pharmaceutical compounds, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Development:
2-methyl-2-(3-nitrophenyl)-1,3-dioxolane is also utilized in the development of agrochemicals, where it can serve as a key intermediate in the synthesis of pesticides or other agricultural chemicals to improve crop protection and yield.
Used in Antimalarial Applications:
2-Methyl-2-(3-nitrophenyl)-1,3-dioxolane has been studied for its potential antimalarial properties, making it a candidate for further research in the development of new treatments for malaria.
Used in Antibacterial Applications:
2-methyl-2-(3-nitrophenyl)-1,3-dioxolane has also shown promise in antibacterial research, indicating its potential use in the development of new antibiotics to combat bacterial infections.
Used in Organic Synthesis:
As a cyclic ketal, 2-methyl-2-(3-nitrophenyl)-1,3-dioxolane is employed in various organic synthesis processes, where it can be used to protect carbonyl groups or as a building block for the synthesis of more complex organic molecules.

InChI:InChI=1/C10H11NO4/c1-10(14-5-6-15-10)8-3-2-4-9(7-8)11(12)13/h2-4,7H,5-6H2,1H3

Upstream product

• 107-21-1 ethylene glycol 
• 121-89-1 3-Nitroacetophenone 
• 98-86-2 acetophenone 
• 3674-77-9 2-methyl-2-phenyl-1,3-dioxolane 

Downstream Products

• 893399-11-6 [4-(2-methyl-[1,3]dioxolan-2-yl)-2-nitrophenyl]acetic acid tert-butyl ester 
• 251955-48-3 2-[3-(2-methyl-[1,3]dioxolan-2-yl)-phenylamino]-3-nitro-benzoic acid 
• 251955-49-4 2-(3-Acetylanilino)-3-nitrobenzoic acid 
• 237428-12-5 2-<3-(1-hydroxyethyl)anilino>-3-nitrobenzoic acid 
• 51226-14-3 2-(3-amino)phenyl-2-methyl-1,3-dioxolane 

Relevant academic research and scientific papers

Instantaneous deprotection of tosylamides and esters with Sml 2/amine/water

(Chemical Equation Presented) Sml2/amine/water mediates instantaneous cleavage of tosyl amides and tosyl esters. Highly hindered, sensitive and functionalized substrates were successfully deprotected in near quantitative yield.

INDOLINONES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS

The invention relates to indolinone compounds of formula (I), wherein Y and R1 to R8 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation and the use thereof for preparing a pharmaceutical composition.

Phenazines and natural products; novel synthesis of saphenic acid

The natural product saphenic acid (6-(1-hydroxyethyl)1- phenazinecarboxylic acid) was synthesized from readily accessible starting materials. The desired product was obtained in an overall yield of 22% for four steps with the key steps being formation of

Aromatic Nitration under Neutral Conditions Using Nitrogen Dioxide and Ozone as the Nitrating Agent. Application to Aromatic Acetals and Acylal

Cyclic acetals derived from aromatic carbonyl compounds can be nitrated smoothly with nitrogen dioxide in ice-cooled dichloromethane or acetonitrile in the presence of ozone and magnesium oxide to give ortho- and para-nitro derivatives as the major product in good combined yields, the acetal ring as a protective group remaining almost intact.An acylal derived from benzaldehyde similarly undergoes nitration on the aromatic ring to give an isomeric mixture of three nitro compounds, in which the ortho and meta isomers predominate, while aromatic orthoesters are rapidly decomposed to give simply the parent esters.Ring nitration under neutral conditions has been interpreted in terms of a nonclassical mechanism, in which nitrogen trioxide is involved as the initial electrophile.

Ozone-mediated Reaction of Aromatic Acetals and Acylal with Nitrogen Dioxide: a Novel Methodology for the Nuclear Nitration of Acid-sensitive Aromatic Compounds under Neutral Conditions

Cyclic acetals 1c-e and 1g can be nitrated smoothly with nitrogen dioxide in ice-cooled dichloromethane in the presence of ozone and magnesium oxide to give mainly ortho- and para-nitro derivatives in good combined yields, the acetal protective group remaining almost intact; acylal 6 is similarly nitrated on the aromatic ring to give a mixture of isomeric nitro derivatives 7, in which the ortho and para isomers predominate.

18O-Isotope Effect in 13C Nuclear Magnetic Resonance Spectroscopy. 5 - Substituent Group Electronic Effects in Substituted Acetophenones

A series of para- and meta-substituted acetophenones were prpared which were highly labeled with 18O at the carbonyl function.The natural abundance 13C NMR spectra of the compounds were recorded and the 18O-isotope-induced shifts of the carbonyl carbon we