51226-44-9

Upstream product

• 70-34-8 2,4-Dinitrofluorobenzene 
• 100-61-8 N-methylaniline 
• 121-69-7 N,N-dimethyl-aniline 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 584-48-5 2,4-dinitrobromobenzene 
• 64-17-5 ethanol 
• 618-40-6 1-Methyl-1-phenylhydrazine 
• 127-09-3 sodium acetate 
• 98-95-3 nitrobenzene 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 

Downstream Products

• 861347-82-2 N¹-methyl-4-nitro-N¹-phenyl-o-phenylenediamine 
• 48154-07-0 N¹-methyl-N¹-phenyl-benzene-1,2,4-triyltriamine 
• 32134-86-4 methyl-dipicryl-amine 
• 51226-45-0 (4-bromo-phenyl)-(2,4-dinitro-phenyl)-methyl-amine 
• 51226-46-1 bis-(2,4-dinitro-phenyl)-methyl-amine 

Relevant academic research and scientific papers

Catalysis by Amine Salts of the Reactions of 1-Chloro- and 1-Fluoro-2,4-dinitrobenzene with N-Methylaniline in Acetonitrile

The second order rate constant kA for the reaction of 1-chloro-2,4-dinitrobenzene with N-methylaniline increases slightly with the addition of quaternary ammonium salts according to the equation kA = k' + k".Values k"/k' of 8.9

2,4-Dinitro-N,N-methylphenylaniline

In the title compound, C13H11N3O4, the substituted aromatic ring has a slightly deformed chair conformation and the unsubstituted ring a deformed boat conformation. The dihedral angle between the mean planes of

One-way valveN-Preparation method of aryl substituted heterocyclic compound (by machine translation)

The invention relates to the technical field of organic chemical synthesis, in particular to an organic chemical synthesis technology. NThe preparation method comprises ?timetime?: 3 molar ratio, reaction 30 - 60 minutes at normal temperature and normal pressure, water adding quenching after reaction, organic solvent extraction 1:1-1 and column chromatography separation (V). Petroleum ether : VEthyl acetate =40:1 - 20:1). NAryl substituted heterocyclic derivatives. Nitrobenzene is used as Ar-H source. N-methylaniline. N-ethylaniline. N-methyl-heterocycles, tetrahydroquinoline, and the like can be used as the amine source. t- BuBuBuBuBuBuBuONa/DMSO/O2 In the system, a direct arylamine reaction of the aromatic ring is achieved. This process has the advantage that the process is simple and high in atomic economy, avoiding the use of expensive transition metals, mild reaction conditions, and environmental-friendly by-products. (by machine translation)

Aryl-Diadamantyl Phosphine Ligands in Palladium-Catalyzed Cross-Coupling Reactions: Synthesis, Structural Analysis, and Application

Synthesis, temperature-dependent NMR structure investigation and utilization of a new, stable and easily accessible aryl-diadamantylphosphine ligand family is reported. The bulky and electron-rich phosphorus center of the ligand enhances the catalytic activity of palladium in cross-coupling reactions of sterically demanding ortho-substituted aryl halides. In our study, we demonstrated the synthetic applicability of the new phosphine ligands in Buchwald-Hartwig and tosyl hydrazone coupling reactions.

Effects of the nucleophile structure on the mechanisms of reaction of 1-chloro-2,4-dinitrobenzene with aromatic amines in aprotic solvents

The kinetics of reactions of 1-chloro-2,4-dinitrobenzene with aniline and several substituted aromatic amines, B, in toluene shows a quadratic dependence of the second-order rate constant, kA, on [B], which is preserved even in the presence of increasing amounts of dimethylaniline, while the reaction with N-methylaniline shows a linear dependence of kA vs [B]. All these results are interpreted by the "dimer nucleophile" mechanism, and confirmed by the effects of a non-nucleophilic hydrogen bond acceptor tertiary amine which show the relevance of the structure of the nucleophile and the role of mixed aggregates in defining the mechanisms of aromatic nucleophilic substitutions with amines in aprotic solvents.

REACTIONS BETWEEN 1-HALOGENO-2,4-DINITROBENZENES AND SUBSTITUTED ANILINES: KINETICS AND EVIDENCE FOR THE PRESENCE OF A MOLECULAR COMPLEX

The title reactions (halogen = F or Cl) have been studied in benzene and in chloroform.The experimental reaction order in aniline is higher than 2 in every case (the value 3 is reached for the fluoro derivative in both solvents).Spectroscopic evidence (1H NMR and UV) indicates the presence of a molecular complex the formation of which (together with a base-catalysed step) is probably responsible for the observed kinetic features.The substituent effect (in aniline) is discussed.