51227-29-3

Usage

Uses

Used in Pharmaceutical Industry:
2-METHYL-1-(3-PYRIDINYL)-1-PROPANONE is used as an intermediate for the production of various pharmaceuticals, contributing to the development of new drugs and medications.
Used in Agrochemical Industry:
2-METHYL-1-(3-PYRIDINYL)-1-PROPANONE is also used as an intermediate in the production of agrochemicals, playing a role in the development of pesticides and other agricultural products.
Used in Organic Synthesis:
2-METHYL-1-(3-PYRIDINYL)-1-PROPANONE is utilized as a building block in organic synthesis, enabling the creation of a wide range of organic compounds for various applications.
Used in Food and Beverage Industry:
As a flavoring and fragrance agent, 2-METHYL-1-(3-PYRIDINYL)-1-PROPANONE is used to enhance the taste and aroma of food and beverage products.
Used in Insect Repellent Production:
2-METHYL-1-(3-PYRIDINYL)-1-PROPANONE is used in the production of insect repellents, helping to create products that protect against insect bites and diseases.
Used in Household and Personal Care Products:
2-METHYL-1-(3-PYRIDINYL)-1-PROPANONE can be found in some household and personal care products, contributing to their effectiveness and functionality.
It is important to handle 2-METHYL-1-(3-PYRIDINYL)-1-PROPANONE with caution, as it can cause irritation to the skin, eyes, and respiratory system if not used properly.

InChI:InChI=1/C9H11NO/c1-7(2)9(11)8-4-3-5-10-6-8/h3-7H,1-2H3

Upstream product

• 100-54-9 pyridine-3-carbonitrile 
• 1068-55-9 isopropylmagnesium chloride 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 74-88-4 methyl iodide 
• 350-03-8 methyl-3-pyridylketone 
• 102994-45-6 2-methyl-1-(pyridin-3-yl)propan-1-ol 
• 626-55-1 3-Bromopyridine 
• 79-30-1 isobutyryl chloride 
• 500-22-1 3-pyridinecarboxaldehyde 
• 67-56-1 methanol 
• 3900-79-6 toluene-4-sulfonic acid isopropylidenehydrazide 
• 144825-44-5 (+/-)-tert-butyl 1-(pyridin-3'-yl)prop-2-en-1-yl carbonate 
• 1570-48-5 1-(pyridin-3-yl)propan-1-one 
• 4621-66-3 thionicotinamide 

Downstream Products

• 54-36-4 metyrapone 
• 1361052-23-4 C₁₅H₁₀F₅NO 
• 1069130-27-3 C₁₇H₁₅NO 
• 102994-45-6 2-methyl-1-(pyridin-3-yl)propan-1-ol 
• 142874-53-1 1-(2-Methoxy-3,4,6-trimethylphenyl)-1-(pyridin-3-yl)-2-methylpropanol 

Relevant academic research and scientific papers

Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by a progressive-fibrosing phenotype. IPF has been associated with aberrant HDAC activities confirmed by our immunohistochemistry studies on HDAC6 overexpression in IPF lung tissues. We herein developed a series of novelhHDAC6 inhibitors, having low inhibitory potency overhHDAC1 andhHDAC8, as potential pharmacological tools for IPF treatment. Their inhibitory potency was combined with lowin vitroandin vivotoxicity. Structural analysis of 6h and structure-activity relationship studies contributed to the optimization of the binding mode of the new molecules. The best-performing analogues were tested for their efficacy in inhibiting fibrotic sphere formation and cell viability, proving their capability in reverting the IPF phenotype. The efficacy of analogue 6h was also determined in a validated human lung model of TGF-β1-dependent fibrogenesis. The results highlighted in this manuscript may pave the way for the identification of first-in-class molecules for the treatment of IPF.

Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents

Schistosomiasis (also known as bilharzia) is a neglected tropical disease caused by platyhelminths of the genus Schistosoma. The disease is endemic in tropical and subtropical areas of the world where water is infested by the intermediate parasite host, t

HMPA-catalyzed transfer hydrogenation of 3-carbonyl pyridines and other N-heteroarenes with trichlorosilane

A method for the HMPA (hexamethylphosphoric triamide)-catalyzed metal-freetransfer hydrogenation of pyridines has been developed. The functional group tolerance of the existing reaction conditions provides easy access to various piperidines with ester or ketone groups at the C-3 site. The suitability of this method for the reduction of other N-heteroarenes has also been demonstrated. Thirty-three examples of different substrates have been reduced to designed products with 45–96% yields.

One-Pot Conversion of Allylic Alcohols to α-Methyl Ketones via Iron-Catalyzed Isomerization-Methylation

A one-pot iron-catalyzed conversion of allylic alcohols to α-methyl ketones has been developed. This isomerization-methylation strategy utilized a (cyclopentadienone)iron(0) carbonyl complex as precatalyst and methanol as the C1 source. A diverse range of allylic alcohols undergoes isomerization-methylation to form α-methyl ketones in good isolated yields (up to 84% isolated yield).

Iron-Catalyzed Methylation Using the Borrowing Hydrogen Approach

A general iron-catalyzed methylation has been developed using methanol as a C1 building block. This borrowing hydrogen approach employs a Kn?lker-type (cyclopentadienone)iron carbonyl complex as catalyst (2 mol %) and exhibits a broad reaction scope. A variety of ketones, indoles, oxindoles, amines, and sulfonamides undergo mono- or dimethylation in excellent isolated yields (>60 examples, 79% average yield).

Methylation of C(sp3)-H/C(sp2)-H bonds with methanol catalyzed by cobalt system

A highly efficient Co-based catalytic system, composed of a commercially available Co salt, a tetradentate phosphine ligand P-(CH2CH2PPh2)3(PP3), and a base (denoted as [Co]/PP3/base), is developed for the methylation of C(sp3)-H and C(sp2)-H bonds using methanol as a methylating reagent. The Co(BF4)2.6H2O/PP3/K2CO3 catalytic system showed high catalytic activity for the methylation of C-H bonds in aryl alkyl ketones, aryl acetonitriles, and indoles, with wide substrate scope and good functional group tolerance, and methylsubstituted products were obtained in good to excellent yields at 100 °C. This cheap, readily available, and highly efficient Co-based catalytic system may have promising applications in methylation reaction using methanol.

Highly efficient C-H hydroxylation of carbonyl compounds with oxygen under mild conditions

A transition-metal-free Cs2CO3-catalyzed α-hydroxylation of carbonyl compounds with O2 as the oxygen source is described. This reaction provides an efficient approach to tertiary α-hydroxycarbonyl compounds, which are highly valued chemicals and widely used in the chemical and pharmaceutical industry. The simple conditions and the use of molecular oxygen as both the oxidant and the oxygen source make this protocol very environmentally friendly and practical. This transformation is highly efficient and highly selective for tertiary C(sp3)-H bond cleavage. OH, so simple! A transition-metal-free Cs2CO 3-catalyzed α-hydroxylation of carbonyl compounds with O 2 provided a variety of tertiary α-hydroxycarbonyl compounds (see scheme; DMSO=dimethyl sulfoxide), which are widely used in the chemical and pharmaceutical industry. The simple conditions and the use of molecular oxygen as both the oxidant and the oxygen source make this protocol very efficient and practical.

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING INHIBITORY EFFECT ON PRODUCTION OF KYNURENINE

The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I): (wherein R6 and R7 may be the same or different and each represent a hydrogen atom or the like, R8, R9, R19, and R11 may be the same or different and each represent a hydrogen atom or the like, R1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and R3 represents optionally substituted aryl or an optionally substituted heterocyclic group).

Double duty for cyanogen bromide in a cascade synthesis of cyanoepoxides

An unprecedented reaction mode of cyanogen bromide has been discovered. Under basic conditions, cyanogen bromide acts as an equivalent of both Br + and CN- to convert enolizable ketones into the corresponding cyanoepoxides in good yields. This unique reaction mode provides new, one-pot access to densely substituted cyanoepoxides from easily available ketones (see scheme). Copyright

KYNURENINE PRODUCTION INHIBITOR

Provided is a kynurenine production inhibitor comprising a nitrogen-containing heterocyclic compound represented by formula (I): (wherein R50 and R51 may be the same or different and each represent a hydrogen atom or the like, G1 and G2 may be the same or different and each represent a nitrogen atom or the like, X represents formula (III): (wherein m1 and m2 may be the same or different and each represent an integer of 0 or 1, Y represents an oxygen atom or the like, and R6 and R7 may be the same or different and each represent a hydrogen atom or the like), R1 represents optionally substituted lower alkyl or the like, R2 represents a hydrogen atom or the like, and R3 represents optionally substituted lower alkyl or the like), and the like.