51269-82-0

Basic information

• Product Name: 5-CHLORO-3-CYANOPYRIDINE
• Synonyms: 5-CHLORO-3-CYANOPYRIDINE;5-CHLORONICOTINONITRILE;3-Chloro-5-cyanopyridine;5-Chloronicotinontrile;5-CHLORONICOTINITRILE;6-Chloronicotinonitrile 2-Chloro-5-cyanopyridine;5-chloro-3-Pyridinecarbonitrile;5-Chloropyridine-3-carbonitrile, 3-Chloro-5-cyanopyridine
• CAS NO: 51269-82-0
• Molecular Formula: C₆H₃ClN₂
• Molecular Weight: 138.55
• Product Categories: Heterocycle-Pyridine series
• Mol File: 51269-82-0.mol

Chemical Properties

• Boiling Point: 208.287 °C at 760 mmHg
• Flash Point: 79.77 °C
• Appearance: /
• Density: 1.331 g/cm³
• Vapor Pressure: 0.215mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -0.50±0.20(Predicted)
• CAS DataBase Reference: 5-CHLORO-3-CYANOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-3-CYANOPYRIDINE(51269-82-0)
• EPA Substance Registry System: 5-CHLORO-3-CYANOPYRIDINE(51269-82-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 51269-82-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-3-cyanopyridine is used as a key intermediate in the synthesis of various pharmaceuticals for [application reason]. Its presence in the synthesis process contributes to the development of new drugs and medicines, enhancing their efficacy and therapeutic potential.
Used in Organic Synthesis:
5-Chloro-3-cyanopyridine is used as a building block in the synthesis of other organic compounds for [application reason]. Its unique chemical structure allows for the creation of a wide range of molecules with diverse applications in various industries, such as agriculture, materials science, and chemical research.
Used in Chemical Research:
5-Chloro-3-cyanopyridine is used as a research compound in the study of chemical reactions and mechanisms for [application reason]. Its reactivity and structural properties make it a valuable tool for understanding the behavior of organochlorines and nitriles in various chemical processes.

InChI:InChI=1/C6H3ClN2/c7-6-1-5(2-8)3-9-4-6/h1,3-4H

Upstream product

• 616-47-7 1-methyl-1H-imidazole 
• 67-66-3 chloroform 
• 930-36-9 1-methyl-1H-pyrazole 

Downstream Products

• 138402-36-5 (5-chloropyridin-3-yl)methanamine 
• 259683-21-1 6-phenylsulfanylpyridine-3-carbonitrile 

Relevant articles and documents

Pyrolysis of 1-substituted pyrazoles and chloroform at 550°C: Formation of α-carboline from 1-benzylpyrazoles

Pyrolysis of 13CH3 labelled 1-methylpyrazole 8 with chloroform at 550°C in a continuous flow reactor yields unlabelled 2-chloropyrimidine 9 and 2-cyanopyrrole 10 labelled at the cyano group. However, pyrolysis of 1-benzylpyrazole 14 with chloroform under similar conditions gives 9,2-phenylpyrimidine 13 and, as the major product, α-carboline 15. Pyrolysis of several substituted 1-(arylmethyl)pyrazoles and the use of 13C and 15N labelled compounds provides direct evidence by which the positions of 7 atoms of 1-benzylpyrazole can be located in the α-carboline. These data support the mechanisms suggested for the formation of 9, 10, and 15.

Reactions of Halogenomethanes in the Vapour Phase. Part 5. The Reactions of Imidazolines, Anils, and 1-Methylimidazole with Chloroform at 550 deg C, and a Comparison with their Liquid-Phase Reactions with Trichloroacetate Ion or Hexachloroacetone and Base

The vapor-phase reactions of imidazolines and anils with chloroform at 550 deg C are compared with their liquid-phase reactions in the presence of hexachloroacetone and base or upon thermolysis with trichloroacetate ion.In the vapour-phase reactions imidazolines, unlike imidazoles, gave non-chlorinated pyrimidines, and 1-methyl-imidazole gave 2-cyanopyrrole and the four 3-chlorocyanopyridines.