51271-34-2

Upstream product

• 74-87-3 methylene chloride 
• 25380-61-4 4-chloro-1,2-benzisothiazole 
• 1194-65-6 2,6-dichloro-benzonitrile 
• 67-68-5 dimethyl sulfoxide 
• 83-38-5 2,6-dichlorobenzaldehyde 

Relevant academic research and scientific papers

Aryl methyl sulfides via SNAr using DMSO as the source of the thiomethyl moiety

A unique synthesis of aryl methyl sulfides is reported proceeding via reduction of dimethylsulfoxide to dimethylsulfide at elevated temperature in the presence of Hunig's base followed by nucleophilic aromatic substitution and demethylation. Activated aryl fluorides, chlorides, and nitrobenzenes are suitable substrates with 13 examples provided. Dimethylsulfoxide serves as a simple and inexpensive formal source of the thiomethyl moiety.

New Synthesis with Elemental Sulfur. - Preparation of 1,2-Benzisothiazoles and Some Secondary Reactions

The preparation of new 1,2-benzisothiazoles 2,3,5 and of thienoisothiazole 4 is described.The thioethers 8 have been obtained from 2 and 3 by ring opening with alcoholate and reaction with halomethyl compounds.On cyclisation, the thioethers 8 give the thionaphthenes 11.The ring systems of thionaphthenopyrimidines 10 and 12 have been prepared from 11.