512786-36-6

Usage

Uses

Used in Pharmaceutical Industry:
(2-bromo-3-methyl-phenyl)-acetic acid methyl ester is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its unique chemical properties allow it to contribute to the development of new medications with potential therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical field, (2-bromo-3-methyl-phenyl)-acetic acid methyl ester is used as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its chemical structure can be modified to create compounds that effectively control, repel, or kill pests and unwanted plants, thus contributing to agricultural productivity and crop protection.
It is important to handle (2-bromo-3-methyl-phenyl)-acetic acid methyl ester with caution as it is potentially hazardous, and its use should be restricted to trained professionals in a controlled environment to ensure safety and proper application.

Upstream product

• 67-56-1 methanol 
• 248920-09-4 2-(2’-bromo-3’-methylphenyl)acetonitrile 
• 248920-11-8 2-bromo-3-methylphenyl acetic acid 
• 66790-58-7 2-bromo-1-(bromomethyl)-3-methylbenzene 
• 576-22-7 2-Bromo-m-xylene 

Downstream Products

• 512786-28-6 2-bromo-1-(2-chloro-ethyl)-3-methyl-benzene 
• 248920-15-2 2-(2-bromo-3-methylphenyl)ethanol 

Relevant academic research and scientific papers

Chiral Magnesium Bisphosphate-Catalyzed Asymmetric Double C(sp3)-H Bond Functionalization Based on Sequential Hydride Shift/Cyclization Process

Described herein is a chiral magnesium bisphosphate-catalyzed asymmetric double C(sp3)-H bond functionalization triggered by a sequential hydride shift/cyclization process. This reaction consists of stereoselective domino C(sp3)-H bond functionalization: (1) a highly enantio- and diastereoselective C(sp3)-H bond functionalization by chiral magnesium bisphosphate (first [1,5]-hydride shift), and (2) a highly diastereoselective C(sp3)-H bond functionalization by an achiral catalyst (Yb(OTf)3, second [1,5]-hydride shift).

A new synthesis of 3-substituted-1H-indenes through reaction of o-(β-magnesioalkyl)phenylmagnesium dihalides with carboxylate esters

A new synthesis of 3-substituted-1H-indenes has been developed through the reaction of o-(β-magnesioalkyl)phenylmagnesium dihalides with carboxylate esters, followed by dehydration of the intermediate 1-substituted-1-indanols. Di-Grignard reagents allowing the synthesis of 3-substituted-, 2-methyl-3-substituted-, and 4-methyl-3-substituted-1H-indenes have been prepared, with overall yields for the two-step sequence ranging from 45 to 95%.