512787-44-9Relevant academic research and scientific papers
1H-indole derivatives as a highly selective cyclooxygenase-2 inhibitor
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, (2008/06/13)
The present invention relates to a novel 1H-indole derivative having a structure of formula 1 and its pharmaceutically acceptable salts as a highly selective cyclooxygenase-2 inhibitor. Wherein, X, Y, and Q are defined in this specification respectively.
Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists
Ahn, Ho-Sam,Arik, Leyla,Boykow, George,Burnett, Duane A.,Caplen, Mary Ann,Czarniecki, Michael,Domalski, Martin S.,Foster, Carolyn,Manna, Mahua,Stamford, Andrew W.,Wu, Yusheng
, p. 2073 - 2078 (2007/10/03)
A series of pyrroloquinazolines has been discovered that represent novel small molecule inhibitors of the intramolecular ligand of the thrombin receptor. Analogs were prepared to study the structure-activity relationships of substitution at the N1, N3, and N7 positions of the heterocycle. Compounds 4e and 4f have been identified with IC50's of 56 and 52 nM, respectively.
