51279-01-7Relevant articles and documents
Promiscuous activity of C-acyltransferase from: Pseudomonas protegens: Synthesis of acetanilides in aqueous buffer
Zad?o-Dobrowolska, Anna,Schmidt, Nina G.,Kroutil, Wolfgang
supporting information, p. 3387 - 3390 (2018/04/05)
Amide bond formation has considerable significance in synthetic chemistry. Although the C-acyltransferase from Pseudomonas protegens has been found to catalyze C-C bond formation in nature as well as in in vitro experiments with non-natural substrates, it is now shown that the enzyme is also able to catalyze amide formation using aniline derivatives as substrates with promiscuous activity. Importantly, the amide formation was enabled in aqueous buffer. Identifying phenyl acetate as the most suitable acetyl donor, the products were obtained with up to >99% conversion and up to 99% isolated yield.
Palladium-catalyzed C-H bond acylation of acetanilides with benzylic alcohols under aqueous conditions
Luo, Feihua,Yang, Jun,Li, Zhengkai,Xiang, Haifeng,Zhou, Xiangge
, p. 2463 - 2469 (2015/04/22)
Palladium-catalyzed dehydrogenative coupling reactions between acetanilides and benzylic alcohols under aqueous conditions are reported. A wide range of benzophenone derivatives could be obtained in good to excellent yields up to 98 %. Mechanism studies showed that a bimetallic palladium cyclopalladated complex might be involved in the catalysis.
BORON-CONTAINING SMALL MOLECULES
-
Page/Page column 139, (2011/06/16)
This invention relates to 6-substituted benzoxaborole compounds of the following formula and their use for treating bacterial infections.