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• 98-03-3 thiophene-2-carbaldehyde 
• 371-40-4 4-fluoroaniline 

Relevant academic research and scientific papers

Synthesis, spectral, electrochemical, antimicrobial and DNA binding/cleavage studies of metal complexes with schiff base of fluoro substituted aniline

A new series of Schiff base complexes of transition (Fe3+, Co2+, Ni2+, Cu2+ and Zn2+) metal were synthesized from 4-fluoroaniline and 2-thiophene carboxaldehyde and structurally characterized by spect

A new catalytic approach for aerobic oxidation of primary alcohols based on a Copper(I)-thiophene carbaldimines

We report here novel Cu(I) thiophene carbaldimine catalysts for the selective aerobic oxidation of primary alcohols to their corresponding aldehydes and various diols to lactones or lactols. In the presence of the in situ generated Cu(I) species, a persistent radical (2,2,6,6-tetramethylpiperdine-N-oxyl (TEMPO)) and N-methylimidazole (NMI) as an auxiliary ligand, the reaction proceeds under aerobic conditions and at ambient temperature. Especially the catalytic system of 1-(thiophen-2-yl)-N-(4-(trifluoromethoxy)phenyl)methanimine (ligand L2) with copper(I)-iodide showed high reactivity for all kind of alcohols (benzylic, allylic and aliphatic). In the case of benzyl alcohol even 2.5 mol% of copper loading gave quantitative yield. Beside high activity under aerobic conditions, the catalysts ability to oxidize 1,5-pentadiol to the corresponding lactol (86% in 4 h) and N-phenyldiethanolamine to the corresponding morpholine derivate lactol (86% in 24 h) is particularly noteworthy.

The Divergent Cascade Reactions of Arylalkynols with Homopropargylic Amines or Electron-Deficient Olefins: Access to the Spiro-Isobenzofuran- b-pyrroloquinolines or Bridged-Isobenzofuran Polycycles

Two divergent cascade reactions of arylalkynols with homopropargylic amines or electron-deficient olefins were developed to synthesize the spiro-isobenzofuran-b-pyrroloquinolines or bridged-isobenzofuran heterocycles in good yields, respectively. One reaction actually involved intramolecular 5-endo-dig hydroamination cyclization-protonation of homopropargylic amines to give cycloiminium ions and intramolecular 5-exo-dig hydroalkoxylation cyclization of arylalkynols to generate isobenzofuran with exocyclic double bond, followed by the nontypical Povarov-type reaction in the presence of PtCl2/FeCl3 cocatalysts. The other underwent intramolecular hydroalkoxylation cycloisomerization of alkynols with the subsequent normal [4 + 2] cycoaddition with dienophiles. Herein, the arylalkynols acted as both "masked" electron-rich olefins and "masked" electron-rich dienes.

Reactions of 2,2,6-Trimethyl-1,3-dioxin-4-one with the Aryl Aldimines Prepared from Thiophene-2-carbaldehyde

The reactions of aryl aldimines derived from thiophene-2-carbaldehyde (5–9) with 2,2,6-trimethyl-1,3-dioxin-4-one (1) were investigated. The new 1,3-oxazin-4-ones and thienylidene acetoacetamides were obtained in good yields. The synthetic utility of the latter via an intramolecular tandem Friedel–Crafts alkylation–acylation to give tetracyclic heterocyclic rings was also explored.

Synthesis, spectral and antimicrobial studies of some Co(II), Ni(II) and Cu(II) Complexes containing 2-thiophenecarboxaldehyde moiety

Some new Schiff base metal complexes of Co(II), Ni(II) and Cu(II) derived from 3-chloro-4-fluoroaniline (HL1) and 4-fluoroaniline (HL 2) with 2-thiophenecarboxaldehyde have been synthesized and characterized by elemental analysis, FT

An efficient three-component synthesis of homoallylic amines catalysed by MgI2 etherate

A three-component reaction of aldehydes, amines and allyltributylstannane was efficiently carried out to afford the corresponding homoallylic amine derivatives in the presence of 20 mol% of MgI2 etherate [(MgI 2?(OEt2)n] under mild and neutral reaction conditions in good to excellent yields.

Facile syntheses of thiophene-substituted 1,4-diazabutadiene (α-diimine) ligands and their conversion to phosphenium triiodide salts

Four novel N-aryl-2-thienyl substituted 1,4-diazabutadiene (α-diimine) ligands 5-8 have been prepared by cyanide ion-catalyzed intermolecular coupling of the appropriate aromatic aldimines. A ligand featuring a phenyl spacer moiety between a thiophene car

Synthesis and hydrosilylation of furan and thiophene N- methylenefluoroanilines in the presence of Pd(I) complex

A series of new N-hetarylaldimines were synthesized by the reactions of furan and thiophene aldehydes with 2-, 3-, and 4-fluoroanilines in the presence of molecular sieves. The reaction of some of the synthesized azomethines with triethoxysilane in the pr